摘要
目的探讨不同剂量阿托伐他汀钙对缺血性脑血管病微出血(CMBs)血清炎性因子和血脂水平的影响。方法回顾性分析西电集团医院在2014年2月—2016年8月期间收治的87例CMBs的临床资料,根据阿托伐他汀钙治疗剂量不同分为强化降脂组、标准降脂组及弱化降脂组,每组29例。3组均给予常规治疗,强化降脂组、标准降脂组和弱化降脂组分别给予阿托伐他汀钙40、20、10 mg/d。观察治疗前后炎性因子水平、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、CMBs部位及数量变化情况,统计不良反应发生情况。结果治疗后,强化降脂组及标准降脂组炎性因子水平均较治疗前和弱化降脂组明显降低,且强化降脂组低于标准降脂组(P<0.05)。治疗后强化降脂组及标准降脂组LDL-C、TC较治疗前和弱化降脂组下降,且强化降脂组低于标准降脂组(P<0.05)。3组CMBs灶数治疗前后组内比较及组间比较差异无统计学意义(P>0.05)。3组不良反应率比较差异无统计学意义(P>0.05)。结论阿托伐他汀钙强化调脂可有效改善CMBs患者血脂水平,降低炎性因子的分泌,进行短期的血脂调节时对CMBs无明显影响,可作为预防缺血性脑血管病的有效药物。
Objective To investigate effects of different doses of Atorvastatin Calcium on serum inflammatory factors and blood lipid levels of microhemorrhage patients with ischemic cerebrovascular disease.Methods Clinical data of 87 microhemorrhage patients with ischemic cerebrovascular disease admitted during February 2014 and August 2016 was analyzed retrospectively,and the patients were divided into intensive lipid-lowering group(n=29),standard lipid-lowering group(n=29)and weakening lipid-lowering group(n=29)according to different doses of Atorvastatin Calcium.All patients received conventional therapies,and then the intensive lipid-lowering,standard lipid-lowering and weakening lipid-lowering groups were treated with Atorvastatin Calcium 40 mg/d,20 mg/d and 10mg/d respectively.Inflammatory factors levels,serum total cholesterol(TC)level,low density lipoprotein cholesterol(LDL-C)level,location and number changes of brain microhemorrhage were observed before and after treatment,and incidence rates of adverse reactions were analyzed in two groups.Results After treatment,levels of inflammatory factors in intensive and standard lipid-lowering groups were significantly lower than those before treatment in the two groups and in weakening lipid-lowering group,and the levels in intensive lipid lowering group were significantly lower than those in standard lipid-lowering group(P<0.05);LDL and TC levels in intensive and standard lipid-lowering groups were significantly lower than those before treatment in the two groups and in weakening lipid-lowering group(P<0.05),and levels in intensive lipid lowering group were significantly lower than those in standard lipid-lowering group(P<0.05).There were no significant differences in number of microhemorrhage focuses before and after treatment among the three groups(P>0.05).There were no significant differences in incidence rates of adverse reactions among the three groups(P>0.05).Conclusion Atorvastatin intensive lipid lowering may improve blood lipid level and reduce secretion of infla
作者
白毅婕
何剑波
苏航
BAI Yijie;HE Jianbo;SU Hang(Department of Neurology,the Second Clinical Medical College of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712046,China;Department of Neurology,Xidian Group Hospital,Xian 710077,China)
出处
《解放军医药杂志》
CAS
2018年第1期82-85,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
陕西省教育厅专项科研计划项目(2010JK485)
关键词
阿托伐他汀钙
缺血性脑血管病
脑微出血
血脂
Atorvastatin calcium
Ischemic cerebrovascular disease
Cerebral microhemorrhage
Blood lipid
