摘要
目的探讨硝苯地平、酚妥拉明和硫酸镁三药联用治疗妊娠高血压的疗效及安全性分析。方法选择本院2016年1月~2017年1月收治的妊娠高血压患者198例,随机分为观察者和对照组两组,各99例,其中对照组患者采取常规硫酸镁治疗,观察者采取硝苯地平、酚妥拉明和硫酸镁三药联合治疗,比较两组患者治疗后的收缩压、舒张压、妊娠结局以及疗效。结果治疗前,两组患者的舒张压和收缩压差异无统计学意义,治疗后与对照组相比,观察者患者舒张压和收缩压下降较为明显(P<0.05);观察组患者新生儿窒息、胎儿窘迫、产后出血、新生儿死亡、宫缩乏力等不良反应发生率明显低于对照组,差异显著具有统计学意义(P<0.05);对照组患者治疗有效率为64.65%,观察者患者治疗有效率为98.99%,观察者有效率明显高于对照组(P<0.05)。结论硝苯地平、酚妥拉明和硫酸镁三药联用治疗妊娠高血压可以明显降低血压,降低不良反应的发生,用药安全性提高,疗效显著,值得临床推广使用。
Objective To investigate the efficacy and safety of nifedipine,phentolamine and magnesium sulfate in the treatment of gestational hypertension.Methods A total of198patients with gestational hypertension in our hospital from January2016to January2017were randomly divided into two groups:observation group and control group(n=99).Patients in control group were treated with conventional magnesium sulfate.Patients in observation group were treated with nifedipine,phentolamine and magnesium sulfate.Systolic blood pressure,diastolic blood pressure,pregnancy outcome and curative effect of patients in two groups were compared after treatment.Results Before treatment,the diastolic and systolic blood pressure of patients in the two groups were not significantly different,compared with control group,the diastolic and systolic blood pressure of paitents in observation group decreased significantly(P<0.05);The incidence of neonatal asphyxia,fetal distress,postpartum hemorrhage,neonatal death,uterine inertia and other adverse reactions in the observation group were significantly lower than in the control group(P<0.05);The effective rate of control group was64.65%,and effective rate of observation group was98.99%,effective rate of observation group was significantly higher than control group(P<0.05).Conclusion The combination of nifedipine,phentolamine and magnesium sulfate in the treatment of pregnancy hypertension can significantly reduce blood pressure and occurrence of adverse reactions,improve the safety of medication,the effect is significant,worthy of clinical application.
作者
冀琛
Ji Chen(Department of gynaecology and obstetrics, Zaozhuang Hospital of Zaozhuang mining group, Zaozhuang, Shandong, 277101, China)
出处
《当代医学》
2018年第9期73-75,共3页
Contemporary Medicine
关键词
硝苯地平
酚妥拉明
硫酸镁
妊娠高血压
疗效
安全性分析
Nifedipine
Phentolamine
Magnesium sulfate
Pregnancy hypertension
Efficacy
Safety analysis
