摘要
目的观察舒洛地特联合贝前列素钠治疗糖尿病肾病(DN)的临床疗效。方法选取牡丹江医学院附属红旗医院收治的DN患者96例。随机分为3组,每组32例。在常规治疗的基础上,舒洛地特组口服舒洛地特胶囊;贝前列素钠组口服贝前列素钠片;联合治疗组口服舒洛地特胶囊和贝前列素钠片。8周后,分别观察3组患者的临床有效率,治疗前后24 h尿蛋白定量(24 h-UTP)、尿白蛋白排泄率(UAER)、尿β_2微球蛋白(β_2-MG)、血清胱抑素C(Cys C)、纤维蛋白原(FIB)、血浆纤溶酶原激活剂抑制物1(PAI-1)及D-二聚体(D-D)的水平变化。结果 8周后,联合治疗组有效率与舒洛地特组和贝前列素钠组比较,差异无统计学意义(P>0.05)。8周后,舒洛地特组的24 h-UTP、UAER、Cys C及FIB较治疗前下降(P<0.05);贝前列素钠组的24 h-UTP、β_2-MG、Cys C及D-D较治疗前下降(P<0.05);联合治疗组的UAER、β_2-MG、24 h-UTP、Cys C、PAI-1、FIB及D-D较治疗前下降(P<0.05)。联合治疗组的24 h-UTP、β_2-MG、FIB及D-D与舒洛地特组比较,差异有统计学意义(P<0.05);联合治疗组的24 h-UTP、UAER、FIB及D-D与贝前列素钠组比较,差异有统计学意义(P<0.05)。结论舒洛地特联合贝前列素钠治疗DN,能有效减少尿蛋白形成,改善肾脏微循环高凝状态、纤溶活性,延缓DN进展,具有肾脏保护作用,且不良反应较少,是治疗DN的有效方法之一,值得临床推广应用。
Objective To observe the curative effect of Sulodexide combined with Beraprost sodium in treatment of diabetic nephropathy(DN).Methods A total of 96 cases of DN in our hospital were divided randomly into 3 groups,32 cases for each group.On the basis of conventional therapy,the groups were further divided into Sulodexide group(oral Sulodexide),Beraprost sodium group(oral Beraprost sodium)and combination group(oral Sulodexide and Beraprost sodium).The clinical efficacy of the 3 groups were observed after 8 weeks of treatment.Levels of 24-hour urine protein quantitative(24 h-UTP),urine albumin excretion rate(UAER),urine 2 microspheres protein(2-MG),serum cystatin C(Cys C),fibrinogen(FIB),plasma plasminogen activator inhibitor 1(PAI-1)and D-Dimer(D-D)were observed pre-and post-treatment.Results Eight weeks later,the clinical efficacy of combination group was compared with Sulodexide group and Beraprost sodium group,but there was no significant difference,respectively(P>0.05).Post-treatment levels of 24 h-UTP,UAER and Cys C in Sulodexide group,24 h-UTP,2-MG and Cys C in Beraprost sodium group and UAER,24 h-UTP,Cys C and 2-MG in combination group decreased significantly than their pre-treatment ones(P<0.05),respectively.Eight weeks later,there were significant differences for levels of 24 h-UTP,2-MG,FIB and D-D in combination group compared with Sulodexide group(P<0.05);there were significant differences for 24 h-UTP,UAER,FIB and D-D in combination group compared with Beraprost sodium group(P<0.05).Conclusions Sulodexide combined with Beraprost sodium in treatment of DN can reduce the formation of urinary protein effectively,improve the renal vascular high coagulation state and fibrinolytic activity,delay the progress of DN and protect kidney.Meanwhile,the side effects are less,which is an effective treatment of DN.
作者
孙源博
刘孝琴
李悦
王云枫
李桂芹
Yuan-bo Sun;Xiao-qin Liu;Yue Li;Yun-feng Wang;Gui-qin Li(Hongqi Hospital Affiliated to Mudanjiang Medical University,Mudanjiang,Heilongjiang 157011,China)
出处
《中国现代医学杂志》
CAS
2018年第9期117-122,共6页
China Journal of Modern Medicine
关键词
舒洛地特
贝前列素钠
糖尿病肾病
疗效
Sulodexide
Beraprost sodium
diabetic nephropathy
curative effect
