摘要
黏连蛋白(cohesin)在DNA修复、细胞周期和基因表达调控等生理过程中发挥重要作用。研究表明,cohesin功能缺陷与肿瘤的发生密切相关。Cohesin的核心蛋白-基质抗原2(STAG2)广泛存在于正常细胞中。近年来,因STAG2在多种肿瘤中的基因突变或蛋白缺失引起研究者的广泛关注。深入研究STAG2基因突变或蛋白缺失对肿瘤发生发展的影响及其相关分子机制,可为肿瘤的诊疗提供新思路,新靶点。该文就STAG2基因在人类恶性肿瘤中的研究现状进行以下综述。
Cohesin plays an important role in multiple physiological processes including DNA repair,cell cycle and gene expression regulation.Studies showed that Cohesin defect is closely associated with tumorigenesis.STAG2,a core protein of cohesion,ubiquitously expressed in normal cells.In recent years,it has widely been paid attention to role of deletion or mutation of STAG2 in occurrence of many tumors.Further research on the effects and molecular mechanisms of STAG2 gene deletion or mutation in tumor development can provide new ideas and new targets for diagnosis and treatment of tumor.This paper reviews the potential function of STAG2 in human malignancies.
作者
徐娟
吴诚龙
唐爱发
Juan Xu;Cheng-long Wu;Ai-fa Tang(Proteomics Laboratory,Zhongshan School of Medicine,Guangzhou,Guangdong 510089,China;Transformational medicine Institute,the Second People’s Hospital of Shenzhen,the First Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong 518035,China)
出处
《中国现代医学杂志》
CAS
2018年第9期60-64,共5页
China Journal of Modern Medicine
基金
国家自然科学基金面上项目(No:81772736)
博士启动基金(No:20131065)
深圳科创委基础研究自由探索项目(No:20170306092002093)
