摘要
目的分析基质金属蛋白酶9(MMP-9)和胱抑素C(Cys-C)水平与急性脑梗死(ACI)患者颈动脉粥样硬化斑块稳定性的关系。方法选取2016年1—9月新疆医科大学第五附属医院神经内科收治的ACI患者189例作为观察组,另选取同期于新疆医科大学第五附属医院体检健康者80例作为对照组。比较两组受试者一般资料和实验室检查指标,MMP-9、Cys-C与ACI患者颈动脉粥样硬化斑块稳定性的关系分析采用有序Logistic回归分析,绘制ROC曲线以评价MMP-9、Cys-C对ACI患者颈动脉粥样硬化斑块稳定性的预测价值。结果两组受试者性别、年龄、高血压病史、空腹血糖(FBG)比较,差异无统计学意义(P>0.05);观察组患者MMP-9、Cys-C水平高于对照组(P<0.05)。观察组患者中发现不稳定性颈动脉粥样硬化斑块较多者83例(占43.9%),稳定性颈动脉粥样硬化斑块较多者67例(占35.5%),无颈动脉粥样硬化斑块者39例(占20.6%)。有序Logistic回归分析结果显示,MMP-9、Cys-C水平较低的ACI患者颈动脉粥样硬化斑块稳定性优于MMP-9、Cys-C水平较高者(P<0.05)。绘制ROC曲线发现,MMP-9预测ACI患者颈动脉粥样硬化斑块稳定性的曲线下面积为0.932[95%CI(0.896,0.968)],最佳截断值为7.96 mmol/L,灵敏度为1.000,特异度为0.750,约登指数为0.075;Cys-C预测ACI患者颈动脉粥样硬化斑块稳定性的曲线下面积为0.794[95%CI(0.732,0.857)],最佳截断值为0.75 mmol/L,灵敏度为0.756,特异度为0.701,约登指数为0.457。结论 MMP-9、Cys-C水平与ACI患者颈动脉粥样硬化斑块稳定性有关,二者对ACI患者颈动脉粥样硬化斑块稳定性的预测价值均较高。
Objective To analyze the relationship between MMP-9,Cys-C and carotid atherosclerostic plaques stability in patients with acute cerebral infarction.Methods From January to September2016,a total of189patients with acute cerebral infarction were selected as observation group in the Department of Neurology,the Fifth Affiliated Hospital of Xinjiang Medical University,meanwhile80healthy people admitted to this hospital for physical examination were selected as control group.General information and laboratory examination results were compared between the two groups,relationship between MMP-9,Cys-C and carotid atherosclerostic plaques stability was analyzed by ordinal Logistic regression analysis,ROC curve was drawn to evaluate the predictive value of MMP-9and Cys-C in predicting carotid atherosclerostic plaques stability.Results No statistically significant differences of gender,age,hypertension history or FBG was found between the two groups(P>0.05),while MMP-9and Cys-C in observation group were statistically significantly higher than those in control group(P<0.05).Of observation group,83cases found mainly unstable carotid atherosclerostic plaques(accounting for43.9%),67cases found mainly stable carotid atherosclerostic plaques(accounting for35.5%),39cases did not found carotid atherosclerostic plaque(accounting for20.6%).Ordinal Logistic regression analysis results showed that,carotid atherosclerostic plaques stability in acute cerebral infarction patients with reduced MMP-9and Cys-C was statistically significantly better than that in acute cerebral infarction patients with elevated MMP-9and Cys-C(P<0.05).ROC curve showed that,AUC of MMP-9in predicting carotid atherosclerostic plaques stability in patients with acute cerebral infarction was0.932〔95%CI(0.896,0.968)〕,the optimum truncation value was7.96mmol/L,the sensitivity was1.000,the specificity was0.075,the Youden index was0.075;AUC of Cys-C in predicting carotid atherosclerostic plaques stability in patients with acute cerebral infarction was0.794〔95%CI(0.7
作者
高华
李沛珊
裴静
王玉玲
杨新玲
GAO Hua;LI Pei-shan;PEI Jing;WANG Yu-ling;YANG Xin-ling(Department of Neurology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;Department of Neurology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830063,China;VIP Ward,Department of Internal Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《实用心脑肺血管病杂志》
2018年第1期34-37,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
新疆医科大学科研创新基金(XYDCX2015110)
