摘要
目的观察清热消痤颗粒治疗炎症性痤疮对患者炎症细胞因子水平的影响。方法选取我院门诊于2013年7月~2015年12月收治的青春期炎症性痤疮患者81例作为研究对象,分为观察组(43例)与对照组(38例)。观察组应用清热消痤颗粒治疗,对照组口服丹参酮颗粒。比较两组治疗前后中医证候积分、治疗总有效率、治疗前后炎症细胞因子水平(IL-4、IFN-γ)、不良反应发生率。结果两组治疗前的中医证候积分差异无统计学意义(P>0.05);治疗后两组中医证候积分均降低(P<0.01),观察组中医证候积分低于对照组,差异有统计学意义(P<0.01)。观察组治疗总有效率为88.4%,高于对照组68.4%,差异有统计学意义(P<0.05)。治疗后两组炎症细胞因子IL-4水平均降低、IFN-γ水平均升高(P<0.05),且观察组IL-4水平低于对照组、IFN-γ水平高于对照组,差异有统计学意义(P<0.05或P<0.01)。观察组与对照组的不良反应发生率分别为7.0%、10.5%,差异无统计学意义(P>0.05)。结论清热消痤颗粒治疗炎症性痤疮可疏风清热、化瘀解毒,切中病机,并降低IL-4、升高IFN-γ,且不良反应少。
Objective To observe the effects of Qingre Xiaocuo granule on the level of inflammation cytokines in patients with inflammation acne.Methods81outpatients with adolescent inflammation acne in our hospital from July2013to December2015were selected as the research objects,they were divided into the observation group(43cases)and the control group(38cases).The observation group was given Qingre Xiaocuo granule,the control group was administrated with Danshentong granule.Integral of TCM symptoms before and after treatment,the total effective rates,the level of inflammation cytokine(IL-4,IFN-γ)before and after the treatment,adverse reaction rates in the two groups were compared.Results There was no significant difference in general integral of TCM symptoms in the two groups before the treatment(P>0.01).After treatment,the scores of two groups significantly decreased(P<0.01),integral of TCM symptoms in the observation group after treatment were significantly lower than the control group(P<0.05).Total effective rate of the observation group was88.4%,which was significantly higher than the control group(68.4%)(P<0.05).After treatment,IL-4in the two groups significantly decreased,IFN-γsignificantly increased(P<0.05),IL-4in the observation group after treatment was significantly lower than the control group,IFN-γwas significantly higher than the control group(P<0.05).There was no significant difference in adverse reaction rates between the observation group(7.0%)and the control group(10.5%)(P>0.05).Conclusion Qingre Xiaocuo granule in treatment of inflammation acne can dispelling-wind and clearing heat,wind-dispersing heat,removing blood stasis and toxin,hit the pathogenesis,reduce IL-4and increase IFN-γ,with less adverse reactions.
作者
崔力
王伟明
CUI Li;WANG Weiming(Shanghai First People's Hospital, Shanghai 200080, China)
出处
《湖南中医药大学学报》
CAS
2017年第12期1404-1407,共4页
Journal of Hunan University of Chinese Medicine
基金
上海市科技计划项目(201501025)
关键词
青春期炎症性痤疮
清热消痤颗粒
炎症细胞因子
adolescent inflammatory acne
Qingre Xiaocuo granule
inflammation cytokines
