摘要
目的比较不同方案治疗早发型子痫前期的疗效和安全性。方法选取2013年5月至2016年10月在我院妇产科诊治的早发型子痫前期孕妇200例,根据随机数字表法分成4组,每组各50例:硫酸镁常规治疗组(A组);硫酸镁常规治疗+丹参注射液组(B组);硫酸镁常规治疗+低分子肝素组(C组);硫酸镁常规治疗+丹参注射液+低分子肝素组(D组)。观察各组脐动脉收缩压与舒张压比值(S/D)、平均动脉压、24 h蛋白尿、分娩方式、延长孕龄时间、新生儿窒息率、母体并发症和不良反应等指标。结果 (1)各组治疗后平均动脉压均显著降低,差异有统计学意义(均P<0.05),但组间比较差异无统计学意义(P>0.05)。各组治疗后S/D均降低(均P<0.05),其中D组治疗后S/D降低明显(P<0.05);各组治疗前后24 h蛋白尿,差异无统计学意义(均P>0.05)。(2)与A组比较,B、C、D组终止妊娠孕周增加(均P<0.05)。(3)B、C、D组孕龄延长时间及新生儿体质量均高于A组,新生儿窒息率低于A组(均P<0.05)。C、D组孕龄延长时间高于B组,D组新生儿窒息率低于B组(均P<0.05)。D组孕龄延长时间及新生儿体质量均高于C组,新生儿窒息率低于C组(均P<0.05)。(4)各组母体并发症及不良反应发生率比较,差异无统计学意义(均P>0.05)。结论硫酸镁联合低分子肝素和/或丹参治疗早发型子痫前期疗效均优于硫酸镁常规治疗,且安全性不低于硫酸镁常规治疗。
ObjectiveTo observe the efficacy and safety of different regimens in treatment early onset preeclampsia.Methods200cases of early onset preeclampsia patients admitted to our hospital were randomly divided into four groups,each group of50cases.group A:magnesium sulfate conventional treatment,group B:magnesium sulfate+salvia miltiorrhiza,group C:magnesium sulfate+low molecular heparin,group D:magnesium sulfate+salvia miltiorrhiza+low molecular heparin.The ratio of systolic and diastolic pressure of fetal umbilical artery(S/D),mean arterial pressure,24h proteinuria,mode of delivery,prolong gestational age,neonatal asphyxia,maternal complications and adverse reactions were compared among the four groups.Results①After treatment,the mean arterial pressure was significantly reduced(P<0.05),but there was no significant difference among groups(all P>0.05).Post treatment S/D decreased significantly(all P<0.05),D group post treatment S/D especially decreased(P<0.05).②Com pared with A group,B,C,D group termination of pregnancy increased gestational weeks(all P<0.05).③B,C,D groups prolonged gestational age and neonatal weight were higher than A group,however the rate of neonatal asphyxia was lower than that of group A(P<0.05).The gestational age of C and D groups were higher than that of group B,and the rate of neonatal asphyxia in group D was lower than that in group B(all P<0.05).④There were no significant difference in the incidence of maternal complications and adverse reactions among four groups(all P>0.05).ConclusionThe efficacy of magnesium sulfate combined with low molecular weight heparin and/or salvia miltiorrhiza in treatment early onset preeclampsia was better than that of magnesium sulfate,and the safety was not lower than that of magnesium sulfate.
作者
黄芸
宋润珞
赵培培
雷云霄
王晨曦
李转珍
HUNAG Yun;SONG Run luo;ZHAO Pei pei;LEI Yun xiao;WANG Chen xi;LI Zhuan zhen(Department of Gynaecology and Obstetrics,Women and Children Health Protection Hospital of Ningling County, Ningling 476000, China;First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China;School of Nursing,Henan University of Science and Technology 263,Luoyang 471023, China;School of Public Heath, Xiamen University, Xiamen 361000, China)
出处
《河南科技大学学报(医学版)》
2017年第4期290-293,共4页
Journal of Henan University of Science & Technology:Medical Science
基金
河南科技攻关项目(152102310086)
关键词
早发型子痫前期
低分子肝素
丹参注射液
安全性
early onset preeclampsia
low molecular heparin
salvia miltiorrhiza
safety