摘要
目的:探讨肝细胞肝癌(hepatocellular carcinoma,HCC)经导管动脉内化疗栓塞(transcatheter arterial ehemoembolization,TACE)后3.0T磁共振成像(magnetic resonance imaging,MRI)弥散加权成像(diffusion-weighted imaging,DWI)表观弥散系数(averaged diffusivity coefficient,ADC)值特征,评价3.0T MRI及ADC值在HCC TACE治疗后监测肿瘤变化的价值。方法:收集2017年1—6月南通大学第二附属医院医院HCC患者25例,所有患者分别于TACE术前、术后1个月进行MRI-DWI的检查,b值选择800 s/mm^2。分析TACE治疗后病灶不同区域ADC值特征。结果:25例病灶中,局部肿瘤残留或复发14例。b值为800 s/mm^2时术后残留肿瘤组织、坏死组织分别为(0.962±0.024)、(1.777±0.094)×10^(-3)mm^2/s,术后复发肿瘤组织于正常肝组织ADC值分别为(1.122±0.054)、(1.500±0.063)×10^(-3) mm^2/s,差异有统计学意义(P<0.05)。结论:3.0T MRI-DWI的ADC值可用于鉴别HCC TACE治疗后坏死组织与复发或残留肿瘤组织,为临床鉴别病变性质提供了一种新的诊断办法。
Objective:To analyze the value of3.0T magnetic resonance imaging(MRI)and diffusion-weight imaging(DWI)in detecting the pathological lesion feature of post-transcatheter arterial ehemoembolization(TACE)in hepatocellular carcinoma(HCC).The characteristics of the averaged diffusivity coefficient(ADC)value were studied to evaluate the changes before and after treatment.Methods:From January to June in2017,Twenty-five HCC patients in the Second Affiliated Hospital of Nantong University were enrolled to receive TACE.One month later,3.0T MRI and DWI(b=800s/mm2)were performed to measure the averaged diffusivity coefficient(ADC)values of different lesions.The ADC values of different lesions were analyzed.Results:Viable tumors occurred in14of25HCC patients after TACE.The ADC value of the tumor necrotic tissue was(1.777±0.094)×10-3mm2/s,with a significant difference to the data(0.962±0.024)×10-3mm2/s of residual tumor.The data(1.122±0.054)×10-3mm2/s of recurrent tumor and the data(1.500±0.063)×10-3mm2/s of normal liver tissue were significantly different(P<0.05).Conclusion:The ADC values of3.0T MRI-DWI can be used to identify the necrosis tissue,residual and recurrent tumor tissue,which provides a new diagnostic method for clinical identification of pathological changes in HCC after TACE.
作者
仇建伟
丁文斌
崔磊
钱俊波
王亚民
葛振明
QIU Jianwei;Ding Wenbin;CUI Lei;QIAN Junbo;WANG Yamin;GE Zhenming(Department of Gastroenterology,the Second Affiliated Hospital of Nantong University,Nantong226001;Department of Intervention,the Second Affiliated Hospital of Nantong University,Nantong226001;Department of Radiology,the Second Affiliated Hospital of Nantong University,Nantong226001)
出处
《南通大学学报（医学版）》
2017年第5期436-438,共3页
Journal of Nantong University(Medical sciences)
基金
南通市指导性课题资助项目(S11955)
关键词
肝细胞肝癌
磁共振成像
扩散加权成像
epatocellular carcinoma
magnetic resonance imaging
diffusion-weighted imaging
