摘要
目的探讨纳美芬辅治对创伤性休克患者血浆肿瘤坏死因子(TNFα)、一氧化氮(NO)及内皮素(ET)水平的影响。方法选择在本院治疗的84例创伤性休克患者作为研究对象,采用随机数表法将其分为观察组与对照组,各42例。对照组予以常规抗休克治疗,观察组加用纳美芬辅助治疗。比较两组TNFα、NO及ET水平变化以及不良反应发生情况。结果治疗前两组TNFα、NO及ET等指标水平相比,差异无统计学意义(P>005);治疗后观察组TNFα、NO及ET等指标水平均明显低于对照组,差异有统计学意义(P<005);两组患者治疗期间均未见明显不良反应。结论创伤性休克患者在常规抗休克治疗基础上加用纳美芬治疗效果确切,能有效降低患者TNFα、NO及ET水平,改善患者预后,值得临床应用。
Objective To discuss the effect of Nami Kaorusukeji on plasma TNF alpha,NO and ET levels in patients with traumatic shock Method Eighty four cases of patients with traumatic shock in our hospital were collected and randomly divided into control group and experimental group,with each group42cases The patients in the control group received routine anti shock treatment,and the patients in the experimental group received nalmefene adjuvant therapy The changes of TNFα,NO and ET levels and adverse reactions were compared between the two groups Results The levels of TNFα,NO and ET in the two groups before treatment were not statistically significant(P>005)After treatment,the levels of TNFα,NO and ET in the experimental group were significantly lower than those in the control group,the difference was statistically significant(P<005)There was no obvious adverse reaction in the two groups during the treatment Conclusion In patients with traumatic shock,routine anti shock treatment combined with nalmefene treatment could effectively reduce the contents of TNFα,NO and ET,and improve the prognosis of patients,which was worthy of clinical application
作者
李岸勇
LI An-yong(Emergency Department,Central Hospital of Xuchang,Xuchang,Henan,461000,China)
出处
《临床研究》
2017年第12期49-50,共2页
Clinical Research
