摘要
目的优选消喘贴敷膏剂的促渗剂。方法采用Franz扩散池,以体外小鼠腹部皮肤为屏障,采用高效液相色谱法测定芥子碱硫氰酸盐的单位面积累积渗透量、渗透吸收速率,对促渗剂进行选择并确定其用量。结果氮酮和丙二醇联用的促渗效果明显优于其他几种促渗剂,确定丙二醇与氮酮的用量比为2∶1,总质量分数为5%。芥子碱硫氰酸盐24 h单位面积累计渗透量为369.59μg·(cm2)-1,透皮速率常数14.19μg·(cm2)-1·h-1,增渗倍数3.19。结论丙二醇与氮酮用量比为2∶1,总用量5%,促渗效果最明显,可作为消喘贴敷膏剂的促渗剂使用。
ObjectiveTo investigate and optimize the penetration enhancers of Xiaochuan emplastrum.MethodsFranz diffusion cell was employed with isolated mice abdominal skin as barrier.The accumulating osmotic quantity per unit area and penetrating absorption rate of Sinapine thiocyanate were determinated by HPLC method.The penetration enhancers were selected and the ratio was determined.ResultsCombination of azone and propylene glycol were better than other kinds of enhancers for penetration effect,the ratio of propylene glycol and azone was2:1.Dosage of azone and propylene glycol was finally optimized to5%of prescription dosage.Under these conditions,cumulative permeation quantity of Sinapine thiocyanate was369.59μg·(cm2)-1,penetration rate of Sinapine thiocyanate was14.19μg·(cm2)-1·h-1and enhancing rate was3.19.ConclusionThe ratio of propylene glycol and azone was2:1,dosage of azone and propylene glycol was5%of prescription dosage,which has a significant penetration effect and can be used as the penetration enhancer of Xiaochuan emplastrum.
作者
王友凤
王冰
曹云飞
张伟
白小英
WANG Youfeng;WANG Bing;CAO Yunfei;ZHANG Wei;BAI Xiaoying(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pharmacy,Juxian People’s Hospital,Shandong Province,Rizhao 276500,China;Department of Pharmacy,Qingdao Haici Medical Corp,Qingdao 266033,China)
出处
《医药导报》
CAS
2017年第11期1306-1309,共4页
Herald of Medicine
基金
青岛市2015-2016年度中医药科研计划(2015-zyy012)
关键词
消喘贴敷膏剂
色谱法
高效液相
促渗剂
芥子碱硫氰酸盐
Xiaochuan Emplastrum
Chromatography,high performance liquid
Penetration enhancer
Sinapine thiocyanate
