摘要
中药黄芩的有效化学成分以黄酮类为主,外用具有抗氧化、防辐射等生物活性,适合制成软膏剂使用。为确定其最佳处方组成,文中进行了辅料筛选研究。首先通过醇提法提取黄芩中的有效成分并制备成干浸膏,然后考察乳化剂、保湿剂和油性基质用量。以耐寒耐热性、离心稳定性、外观、肤感的综合评分作为成型性考察指标,经正交筛选确定软膏剂的最佳处方。硬脂酸、羊毛脂、凡士林和单硬脂酸甘油酯以20∶4∶15∶6的质量比组成复合油相,吐温-80为乳化剂,甘油为保湿剂,复合油相、吐温-80和甘油的加用量分别为40%、5%和3%。该研究为黄芩总黄酮提取物软膏剂的成型工艺奠定了基础。
Scutellaria baicalensis Georgi is an important heat-cleaning medicine with bioactivities of anti-oxidation and anti-ultraviolet radiation through topical drug delivery.The flavonoid ingredients are main efficient components in S.baicalensis,which are suitable for ointment preparation after subtracted.In this study,the best formulation was established by screening excipients of total flavonoids extract ointment.Firstly,active ingredients were extracted by alcohol extraction.Afterwards,orthogonal screening was used to determine the optimal formulation of ointment through investigating the percentage of emulsifier,humectant and the oil phase,in which comprehensive scoring of cold and heat resistance,centrifugal stability,appearance and skin-feeling was set as evaluation indicator.In the formulation screening,multiples composition of oil phase was used,in which the mass proportion of stearic acid/lanolin/petrolatum/glyceryl monostearate was20:4:15:6.Meanwhile,tween-80was used as emulsifier and glycerol was usd as humectant.In the selected formulation,the percentage(mass fraction)of oil phase,tween-80and glycerol was40%,5%and3%.This study provided the basis for the ointment preparation of total flavonoid extracts from S.baicalensis.
作者
王红茜
凡苗振
邹琴
顾无为
刘黎瑶
WANG Hong-qian;FAN Miao-zhen;ZOU Qin;GU Wu-wei;LIU Li-yao(College of Basic Science, Tianjin Agricultural University, Tianjin 200384, China;Department of Oncology, Hebei Provincial Chest Hospital, Shijiazhuang 050041, China)
出处
《天津农学院学报》
CAS
2017年第4期33-37,共5页
Journal of Tianjin Agricultural University
基金
国家自然科学基金面上项目"中草药小檗碱对铜绿微囊藻光合作用影响的研究"(31170442)
关键词
黄芩总黄酮
软膏剂
正交设计
处方筛选
total flavonoid extracts
ointment
orthogonal screening
formulation selevtion
