摘要
目的探讨紫杉醇联合顺铂及5-氟尿嘧啶(PCF)方案和奥沙利铂联合亚叶酸钙及5-氟尿嘧啶(FOLFOX4)方案治疗中晚期胃癌的临床疗效。方法 80例中晚期胃癌患者,根据治疗方案不同分为PCF组和FOLFOX4组,每组40例。PCF组采用PCF方案治疗,FOLFOX4组采用FOLFOX4方案治疗,比较两组患者临床治疗效果和毒副反应发生情况。结果 PCF组患者临床治疗总有效率为57.5%,FOLFOX4组患者临床治疗总有效率为55.0%,两组患者临床治疗总有效率比较差异无统计学意义(P>0.05)。PCF组患者发生白细胞减少2例、血小板减少5例、手足综合征4例、恶心呕吐3例,FOLFOX4组患者发生白细胞减少2例、血小板减少4例、手足综合征5例、恶心呕吐4例,两组患者毒副反应发生情况比较差异无统计学意义(P>0.05)。结论 PCF方案和FOLFOX4方案治疗中晚期胃癌疗效相当,且患者均可耐受。
Objective To discuss the clinical efficacy of paclitaxel combined with cisplatin and5-fluorouracil(PCF)regimen and oxaliplatin combined with calcium leucovorin and5-fluorouracil(FOLFOX4)regimen in the treatment of advanced gastric cancer.Methods A total of80patients with advanced gastric cancer were divided by different treatment regimen into PCF group and FOLFOX4group,with40cases in each group.PCF group was treated with PCF regimen,and FOLFOX4groups was treated with FOLFOX4regimen.Comparison were made on clinical treatment effect and occurrence of toxic and side effects between two groups.Results PCF group had clinical total treatment effective rate as57.5%,which was55.0%in FOLFOX4group,and both groups had no statistically significant difference in clinical total treatment effective rate(p>0.05).PCF group had2cases of leukopenia,5cases of thrombocytopenia,4cases of hand-foot syndrome,3cases of nausea and vomiting,while FOLFOX4group had2cases of leukopenia,4cases of thrombocytopenia,5cases of hand-foot syndrome,4cases of nausea and vomiting,and both groups had no statistically significant difference in occurrence of toxic and side effects(p>0.05).Conclusion PCF and FOLFOX4regimen shows equal efficacy in treating advanced gastric cancer,it is tolerable by patients.
作者
陈伟
CHEN Wei(Department of Tumor, Donggang City Traditional Chinese Medicine Hospital, Donggang 118300, China)
出处
《中国现代药物应用》
2017年第23期77-79,共3页
Chinese Journal of Modern Drug Application
