摘要
以2,4,6–三羟基苯乙酮为原料,通过保护、羟醛缩合、环化、碘代以及Sonogashira反应合成了2个新的8位对甲氧苯炔基取代黄酮化合物.同时,从4,6–二羟基橙酮和金鱼草素出发,通过保护、碘代以及Sonogashira反应合成了2个新的7位对甲氧苯炔基取代橙酮化合物.以常见黄酮和橙酮为母核,探讨8位对甲氧苯炔基取代黄酮和7位对甲氧苯炔基取代橙酮衍生物的合成方法.这些化合物的合成为进一步对黄酮化合物8位以及橙酮的7位进行化学修饰奠定了良好的基础.
Two new8-((4-methoxyphenyl)ethynyl)flavones were prepared from2,4,6-trihydroxyl acetophenone throughprotection,aldol,cyclization,iodination and Sonogashira reactions.At the same time,two new7-((4-methoxyphenyl)ethynyl)aurones were prepared from commercial available4,6-hydroxyl aurone and aureusidin through protection,iodination and Sonogashira reactions.The synthesis of8-((4-methoxyphenyl)ethynyl)flavones and7-((4-methoxyphenyl)ethynyl)aurones was conducted with flavone and aurone as nucleus.The synthesis of these compounds canfacilitate the chemical modification of8-position of flavones as well as7-position of aurones.
作者
杨珂
潘国军
黄淇尧
芦逵
YANG Ke;PAN Guojun;HUANG Qiyao;LU Kui(College of Biotechnology,Tianjin University of Science & Technology,Tianjin 300457,China)
出处
《天津科技大学学报》
CAS
北大核心
2017年第5期28-33,共6页
Journal of Tianjin University of Science & Technology
基金
国家自然科学基金资助项目(21202118)
