摘要
目的探讨同型半胱酸、精子DNA碎片指数与严重生精障碍男性的精子计数之间的相关性研究。方法 2015年12月~2017年2月期间在医院就诊的严重生精障碍男性患者56例,按WHO标准分为严重无、少精子症组25例和弱精子症组31例,对照组为无生育障碍的男性27例。对所有纳入研究者进行精子参数、精子DNA碎片指数和血清Hcy水平的检测。结果严重生精障碍男性的精子DNA碎片指数和Hcy均高于正常对照组。精子DNA碎片指数与血清Hcy水平、精子浓度呈正相关,而Hcy水平和精子浓度呈负相关。结论 Hcy水平和精子DNA碎片指数的升高,可能是严重生精障碍男性的重要病因,但其具体机制有待进一步研究。
Objective To explore research on correlation between homocysteine,sperm DNA fragmentation index and sperm count of males with severe spermatogenesis dysfunction.Methods56male patients with severe spermatogenesis dysfunction who were treated in our hospital from December2015to February2017were selected.According to WHO standard,they were divided into the severe azoospermia and oligospermia group with25cases and the asthenospermia group with31cases.In the control group,there were27males without fertility barrier.Sperm parameters,sperm DNA fragmentation index and serum Hcy level of all included research objects were detected.Results Sperm DNA fragmentation index and Hcy level of males with severe spermatogenesis dysfunction were both significantly higher than those of the normal control group.Sperm DNA fragmentation index was positively correlated with serum Hcy level and sperm concentration while Hcy level was negatively correlated with sperm concentration.Conclusion Improvements of Hcy level and sperm DNA fragmentation index may be the main causes for males with severe spermatogenesis dysfunction but concrete mechanism needs to be further studied.
作者
何海洪
郭伟权
柯娟玉
兰希
吴润安
周义文
HE Haihong;GUO Weiquan;KE Juanyu;LAN Xi;WU Run-an;ZHOU Yiwen(Clinical Laboratory Center, Shenzhen Hospital of Southern Medical University, Shenzhen 518110, China)
出处
《中国医药科学》
2017年第11期14-17,共4页
China Medicine And Pharmacy
基金
广东省深圳市宝安区医疗卫生科研项目(2016CX300)
