摘要
目的评价丹参多酚酸盐注射液预防妇科患者术后静脉血栓形成(DVT)的效果。方法 100例盆腔手术患者,以治疗方式不同分为对照组(低分子肝素钙+梯度压力弹力袜)和观察组(低分子肝素钙+梯度压力弹力袜+丹参多酚酸盐注射液),各50例。比较两组患者凝血指标、血流动力学指标、DVT发生率及不良反应发生情况。结果观察组患者血小板计数(PLT)、凝血酶原时间(PT)、纤维蛋白原(Fbg)、D-二聚体(D-D)水平明显低于对照组,差异具有统计学意义(P<0.05)。观察组股静脉血流峰速度(Vp)和平均速度(Va)明显高于对照组,差异具有统计学意义(P<0.05)。观察组术后7d内共发生1例DVT,DVT发生率为2.0%;对照组发生7例DVT,DVT发生率为14.0%。观察组DVT发生率明显低于对照组,差异具有统计学意义(χ~2=4.891,P<0.05)。两组患者治疗期间均未出现药物过敏以及重要器官功能损害等不良反应。结论在妇科手术患者术后康复期间给予低分子肝素钙+梯度压力弹力袜+丹参多酚酸盐注射液的联合疗法可有效改善凝血功能与血流动力学指标,减少深静脉血栓发生率,预防效果显著。
Objective To evaluate effect by salvianolate injection in prevention of postoperative deepvenous thrombosis(DVT)in gynecologic patients.Methods A total of100patients receiving pelvic operationwere divided by different treatment measures into control group(low molecular weight heparin calcium+gradientpressure stretch socks)and observation group(low molecular weight heparin calcium+gradient pressure stretchsocks+salvianolate injection),with50cases in each group.Comparison was made on coagulation indexes,hemodynamics indexes,incidence of DVT and occurrence of adverse reactions between the two groups.ResultsThe observation group had obviously lower blood platelet count(PLT),prothrombin time(PT),fibrinogen(Fbg)and D-dimer(D-D)levels than the control group,and their difference had statistical significance(P<0.05).The observation group had much higher venous blood flow peak velocity(Vp)and average velocity(Va)than thecontrol group,and the difference had statistical significance(P<0.05).The observation group had1case withDVT in postoperative7d,with incidence of DVT as2.0%,while the control group had7cases with DVT,withincidence of DVT as14.0%.The observation group had obviously lower incidence of DVT than the control group,and their difference had statistical significance(χ2=4.891,P<0.05).There was no case with drug allergy andvital organ function damage as adverse reactions in both groups during treatment.Conclusion Implement of(lowmolecular weight heparin calcium+gradient pressure stretch socks+salvianolate injection in combined therapyfor gynecologic patients during their postoperative rehabilitation can effectively improve coagulation function andhemodynamics indexes,and lower incidence of deep venous thrombosis,along with excellent prevention effect.
作者
余卢妹
YU Lu-mei(Dongguan City Changan Hospital, Dongguan 523843, China)
出处
《中国现代药物应用》
2017年第10期81-83,共3页
Chinese Journal of Modern Drug Application
基金
东莞市社会科技发展项目(项目编号:201650715001436)
关键词
丹参多酚酸盐
妇科患者
静脉血栓
预防效果
Salvianolate
Gynecologic patients
Deep venous thrombosis
Prevention effect
