摘要
如何辨识有效成分是中药新药研究中的关键科学问题之一。中药作用的整体性、组成成分的多样性、作用靶点的复杂性以及成分间相互作用的难以预测性,使传统药效物质研究方法的效率普遍不高。基于"定量组效关系"研究思想,多组分药物的化学组成与其生物活性间同样存在定量相关关系,组效学研究可帮助辨识中药的有效成分。本文对目前组效研究中常用的方法和技术进行综述,为中药药效物质基础研究提供借鉴。
It is one of key scientific problems to identify the effective compounds in the study on new TCM.Because of the integrity of the effects of TCM,the diversity of constituents,the complexity of the targets and theunpredictability of the interaction among the components,the efficiency of the traditional efficacy substance researchmethod is generally not high.Based on the research thought of quantitative composition-activity relationship,thereare inevitable quantitative correlation between chemical compositions and its biological activity.The quantitativecomposition-activity relationship research is an effective method to detect the effective compounds.This articlereviewed the common methods and technologies used in the quantitative composition-activity relationship research,with a purpose to provide some references for the study on basic effective components in TCM.
作者
柏冬
王瑞海
刘丽梅
BAI Dong;WANG Rui-hai;LIU Li-mei(Institute of Basic Theory of TCM,China Academy of Chinese Medical Sciences, Beijing 100700, China)
出处
《中国中医药信息杂志》
CAS
CSCD
2017年第6期126-130,共5页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家重点基础研究发展计划(2012CB518401)
关键词
中药组效
物质基础
药效评价
多元统计
神经网络
综述
quantitative composition-activity relationship of TCM
basic effective components
evaluating pharmacological effect
multivariate statistics
neural network
review
