摘要
目的研究右美托咪定用于重症监护病房机械通气患者镇痛镇静的临床疗效。方法 80例重症监护病房机械通气患者作为研究对象,按照随机分配原则将其分为观察组和参照组,每组40例。参照组患者应用咪达唑仑进行镇痛镇静,观察组患者应用右美托咪定进行镇痛镇静。对比两组患者的视觉模拟评分法(VAS)评分、唤醒时间、机械通气时间以及不良反应发生情况。结果两组患者机械通气时间比较,差异无统计学意义(t=0.57,P>0.05);观察组患者的VAS评分低于参照组、唤醒时间短于参照组,差异均具有统计学意义(t=12.78、19.09,P<0.05)。观察组的不良反应发生率为7.50%,低于参照组的25.00%,差异具有统计学意义(P<0.05)。结论重症监护病房机械通气患者应用右美托咪定进行镇痛镇静,可以起到积极的效果,值得在临床上大力推广。
Objective To study the clinical curative effect of dexmedetomidine applied for tranquillizing and calming of intensive care unit patients with mechanical ventilation.Methods A total of80intensive care unit patients with mechanical ventilation as study subjects were randomly divided into observation group and control group,with40cases in each group.The control group received midazolam for tranquillizing and calming,and the observation group received dexmedetomidine for tranquillizing and calming.Comparison were made on visual analogue scale(VAS)score,wake-up of time,mechanical ventilation time and adverse reactions occurrence intwo groups.Results Both groups had no statistically significant difference in mechanical ventilation time(t=0.57,P>0.05).The observation group had lower VAS score than the control group and shorter wake-up time than thecontrol group.Their difference had statistical significance(t=12.78,19.09,P<0.05).The observation group had lower incidence of adverse reactions as7.50%than25.00%in the control group,and the difference had statistical significance(P<0.05).Conclusion Dexmedetomidine shows active effect for tranquillizing and calming of intensive care unit patients with mechanical ventilation,and it is worth to be promoted vigorously in clinic.
作者
刘世专
刘红梅
黄卫俊
陈时松
孙成晖
LIU Shi-zhuan;LIU Hong-mei;HUANG Wei-jun(Guangdong Province Yangchun City People’s Hospital, Yangchun 529600, China)
出处
《中国现代药物应用》
2017年第7期95-97,共3页
Chinese Journal of Modern Drug Application
关键词
右美托咪定
重症监护
机械通气
镇痛镇静
Dexmedetomidine
Iintensive care
Mechanical ventilation
Tranquillizing and calming
