摘要
目的:本文主要研究分析虎杖和山楂提取物在治疗冠状动脉粥样硬化斑块过程中的稳定性影响。方法:分类选取了2013年7月-2015年4月来我院就诊的64例稳定性冠心病患者为研究对象,将上述患者按治疗方案分成两组:阿托伐他汀组、虎杖和山楂提取物组。两组疗程均为12个月。使用医疗设备来观察测定患者的冠状动脉狭窄率、斑块数目以及冠状动脉钙化积分的变化情况,同时检测血瘀证记分和血脂水平的改变状况。结果:接受治疗后,两组患者的病情均有了明显的改善,虎杖和山楂提取物组患者的冠状动脉狭窄率变化值较阿托伐他汀组明显减小(P<0.05),虎杖和山楂提取物组的冠状动脉斑块数目及冠状动脉钙化积分均有了明显的减少,与阿托伐他汀组的差异显著(P<0.05)。虎杖和山楂提取物在治疗过程中还能有效降低血清总胆固醇(TC)并升高血清高密度脂蛋白胆固醇(HDL-C)的浓度,最终达到降低动脉粥样硬化指数(AI)的目的,与阿托伐他汀组有明显差异(P<0.05)。治疗后虎杖和山楂提取物组及阿托伐他汀组血瘀证计分相对于治疗前均明显降低(P<0.05)。结论:虎杖和山楂提取物在治疗稳定性冠心病时可以达到更好的临床效果,尤其是这两组药物的治疗效果与阿托伐他汀药物无明显差异,也满足临床需要。
Objective:To investigate the stability of extracts of Huzhang and Shanzha on coronary atherosclerotic plaque.Methods:From July2013to April2015,64patients were divided into the atorvastatin group and the extracts of Huzhang and Shanzha group,12months as a course.Coronary artery stenosis rate,plaque number,the Xueyu syndrome score,blood lipid levels and coronary calcification score in two groups were observed.Results:After treatment,patients in two groups showed a significant improvement in the condition.The stenosis of coronary artery stenosis in the extracts of Huzhang and Shanzha group was significantly lower(P<0.05).Coronary arteryplaque number and coronary calcification score were significantly decreased in the extracts of Huzhang and Shanzha group(P<0.05).Extracts of Huzhang and Shanzha can also effectively reduce serum total cholesterol and elevate serum high-density lipoprotein cholesterol concentration,and ultimately to reduce the purpose of atherosclerosis index(P<0.05).After treatment,the Xueyu syndrome score in two groups were significantly decreased(P<0.05).Conclusion:Extracts of Huzhang and Shanzha on coronary atherosclerotic plaque shows a good effect;there was no significant difference compared with atorvastatin.
出处
《中医临床研究》
2017年第5期28-29,共2页
Clinical Journal Of Chinese Medicine
