摘要
目的采用Meta分析的方法探讨勃起功能障碍(ED)与冠状动脉粥样硬化性心脏病(冠心病,CHD)及全因死亡率的关系。方法计算机检索Pub Med、Embase、CNKI、Wanfang Data、CBM和VIP数据库,检索时限均为建库至2016年6月,查找ED与CHD及全因死亡率相关性的队列研究,由2位作者独立进行文献筛选、资料提取及质量评价后,采用Stata 14.0软件进行Meta分析。结果最终纳入11个队列研究,其中7个研究报告了ED与CHD的相关性,9个研究报告了ED与全因死亡率的相关性。Meta分析结果显示,ED可能会增加CHD(RR=1.54,95%CI:1.41~1.67,P<0.001)和全因死亡率的发病风险(RR=1.47,95%CI:1.18~1.84,P=0.001)。无明显发表偏倚存在。结论 ED可能会增加CHD及全因死亡率的发病风险。因此,临床治疗ED患者可能会有降低CHD及全因死亡率的发病风险。
Objective To evaluate the association between erectile dysfunction (ED) and risk of coronary heart disease (CHD) and all-cause mortality by meta-analysis. Methods The databases of PubMed, Embase,CNKI, Wanfang Data, CBM and VIP were retrieved for collecting cohort studies reported the association between ED and risk of CHD and all-cause mortality. Two authors independently screened literatures, extracted data and assessed the quality of included studies. Then meta-analysis was performed using Stata 14.0 software. Results A total of 11 cohort studies were included, in which seven reported the association between ED and risk of CHD and nine reported the association between ED and risk of all-cause mortality. The results of meta-analysis showed that ED was associated with increased risk of CHD (RR=1.54, 95%CI: 1.41~1.67, P<0.001) and all-cause mortality (RR=1.47, 95%CI: 1.18~1.84, P=0.001). No obvious publication bias was detected. Conclusion ED might increase the risk of CHD and all-cause mortality. Therefore, to cure ED patients might decrease the risk of CHD and allcause mortality in clinical practice.
作者
刘涛
田国祥
曾宪涛
翁鸿
刘同族
王行环
LIU Tao;TIAN Guo-xiang;ZENG Xian-tao;WENG Hong;LIU Tong-zu;WANG Xing-huan(Department of Urology, The Sixth Hospital of Wuhan (Affiliated to Jianghan University), Wuhan 430015, China)
出处
《中国循证心血管医学杂志》
2017年第3期269-272,共4页
Chinese Journal of Evidence-Based Cardiovascular Medicine
基金
国家重点研发计划专项基金(2016YFC0106300)
关键词
勃起功能障碍
冠心病
全因死亡率
META分析
Erectile dysfunction
Coronary heart disease
All-cause mortality
Meta-analysis
