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组织蛋白酶S的研究进展 被引量:10

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摘要 组织蛋白酶S(Cat S)是半胱氨酸蛋白酶的重要一员,主要分布在淋巴结、脾脏、肺等器官,多在表达主要组织相容性复合物Ⅱ的细胞中表达,在抗原递呈中发挥重要作用,参与疾病的发生、发展过程。Cat S还与炎症因子相互作用,参与体内免疫及炎症反应,在心血管、免疫系统和肿瘤等疾病的发生、发展过程中发挥重要作用。本文通过概述Cat S的结构、与疾病的关系、上下游通路、活性检测方法及抑制剂等方面内容,为今后开展Cat S的研究提供部分参考。
出处 《浙江医学》 CAS 2017年第6期488-492,共5页 Zhejiang Medical Journal
基金 浙江省自然科学基金资助项目((LY17H100007) 浙江中医药大学校级科研基金项目(2015ZZ10)
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