摘要
目的探讨血清IgA水平对血清果糖胺(FMN)水平的影响。方法回顾性分析河北省沧州市3家医院2012年1月1日—2015年12月31日收治的247例初诊多发性骨髓瘤(MM)患者血清样本中FMN和免疫球蛋白含量,以同期50例IgA增高的慢性肝病(CLD)患者作为对照组。247例MM包括IgG型133例、IgA型83例、IgM型31例,所有患者均排除糖尿病。结果 IgA型MM组FMN水平明显高于对照组(P<0.05),IgG型MM组、IgM型MM组与对照组比较,差异无统计学意义(P>0.05)。IgA型MM组IgA水平与FMN水平呈正相关(r=0.785,P<0.05),对照组IgA水平与FMN水平无明显相关性(r=0.241,P>0.05)。结论对于不明原因的FMN升高需考虑IgA水平的影响。
Objective To investigate the influence of serum IgA level on serum fructosamine (FMN) level.Methods The levels of FMN and immunoglobulins in serum samples were analyzed for 247 newly-diagnosed multiple myeloma (MM) patients in 3 hospitals of Cangzhou from January 1,2012 to December 31,2015. A total of 50 patients with chronic liver diseases(CLD) who had high IgA levels were enrolled as control group.There were IgG type (133 cases),IgA type (83 cases)and IgM type (31 cases)in the 247 MM patients. All the patients were excluded with diabetes mellitus. Results FMN levels of IgA type MM group were higher than those of control group(P<0.05). There was no statistical significance among IgG type MM group,IgM type MM group and control group (P>0.05). The IgA level of IgA type MM group is related positively to FMN level(r=0.785,P<0.05),and the IgA level in control group has no correlation(r=0.241,P>0.05). Conclusions IgA level should be considered,if FMN is elevated for unknown reasons.
作者
张靖宇
陈立新
王丽芳
胡海涛
王军
范洪
ZHANG Jingyu;CHEN Lixin;WANG Lifang;HU Haitao;WANG Jun;FAN Hong(Department of Clinical Laboratory Diagnostics,Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine,Cangzhou 061001,Hebei,China)
出处
《检验医学》
CAS
2017年第3期182-184,共3页
Laboratory Medicine
基金
河北省卫生和计划生育委员会重点科技研究计划(20150540)
关键词
果糖胺
IGA
多发性骨髓瘤
糖尿病
慢性肝病
Fructosamine
IgA
Multiple myeloma
Diabetes mellitus
Chronic liver diseases
