摘要
血管紧张素转化酶(angiotensin-converting enzyme,ACE)抑制肽是一类从食源性蛋白质中分离得到的具有降高血压活性的多肽。由于其降血压效果好,而且没有降压药物的毒副作用从而引起了广泛关注。近年来,ACE抑制肽的构效关系研究成为研究重点。结构生物信息学研究表明,ACE抑制肽的ACE抑制能力不仅与其分子质量有关,而且与其氨基酸序列以及其立体空间构象之间存在高度相关性。ACE抑制肽的抑制类型与ACE抑制活性、构效关系也存在一定相关性。对ACE抑制肽构效关系进行深入研究将有助于指导开发高活性的功能性食品及降血压药物。
Angiotensin converting enzyme(ACE)inhibitory peptides are a category of peptides derived from food proteins which can reduce blood pressure.ACE inhibitory peptides have gained extensive concerns because they can reduce blood pressure without side effects as antihypertensive drugs.In recent years,the structure-activity relationship of ACE inhibitory peptides has become one of the research focuses.Structural bioinformatics showed that the activity of ACE inhibitory peptides is related to not only their molecular masses,but also their amino acid sequences and spatial conformation.It is also found that the type of inhibit of ACE inhibitory peptides is related to their activity and structure-activity relationship.Intensive studies on ACE inhibitory peptide structure-activity relationship will be helpful to guide the development of new functional foods and antihypertensive drugs.
作者
王晓丹
薛璐
胡志和
张琦
李艳军
夏磊
WANG Xiaodan;XUE Lu;HU Zhihe;ZHANG Qi;LI Yanjun;XIA Lei(College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China;Tianjin Key Laboratory of Food and Biotechnology, Tianjin 300134, China;Beaufour-Ipsen (Tianjin) Pharmaceutical Co. Ltd., Tianjin 300384, China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2017年第5期305-310,共6页
Food Science
基金
天津市应用基础与前沿技术研究计划重点项目(14JCZDJC34500)
天津市科技支撑计划项目(14ZCZDNC00017)
天津市高等学校创新团队项目(TD12-5049)
天津市大学生创新创业训练计划项目(201510069050)
关键词
ACE抑制肽
构效关系
氨基酸序列
ACE inhibitory peptide
structure-activity relationship
amino acid sequences
