摘要
目的观察调强放疗联合同步替吉奥治疗复发直肠癌的近期疗效及并发症。方法对39例术后复发直肠癌患者,采用调强放疗,1.8~2.0 Gy/次,5次/周,预防剂量45~48 Gy后肿瘤推量至60~66 Gy。同步口服替吉奥胶囊化疗[80 mg/(m2·d),分2次餐后1小时口服,服2周,停1周]。结果有36例完成治疗,依从性好。放疗结束后3个月时CR 7例,PR 27例,SD 5例,有效率(RR)为87.2%,疾病控制率(DCR)为100%。主要不良反应为消化道反应、血液学毒性、肛周皮肤反应,多为1、2级。结论调强放疗联合替吉奥对复发直肠癌的近期疗效好,显著改善患者生活质量,急性并发症可耐受。
Objective To observe the recent curative effect and complications for the treatment of recurrent colorectal cancer for Intensity ModulatedRadiationtherapy combined synchronization chemotherapy for Gimeracil and Oteracil Porassium.Methods39cases of postoperative recurrenceof rectal cancer patients,used of intensity modulated radiation therapy,1.8-2.0Gy per fraction,five fractions per week,after prevention dose of45-48Gy,push the tumor amount to60-66Gy.Synchronous oral chemotherapy for Gimeracil and Oteracil Porassium capsule[80mg/(m2·d),1hourafter the meal points2times of oral,takes2weeks,stop1week].Results36patients underwent treatment,compliance is good.3months after the radiation,CR7,PR27,SD5cases respectively,efficient(RR)was87.2%,the disease control rates(DCR)was100%.Major adverse events of the digestivetract,hematology toxicity,anus periderm skin reaction,more than1,level2.Conclusion Combined Intensity Modulated Radiotherapy withGimeracil and Oteracil Porassium for recurrence of rectal cancer,The recent curative effect is good,improve patient quality of life,acute complicationscan be tolerated.
出处
《当代医学》
2017年第7期87-89,共3页
Contemporary Medicine
关键词
直肠肿瘤/肿瘤复发
放射疗法
同步化疗
替吉奥
Colorectal cancer /cancer recurrent
Radiotherapy
Synchronization chemotherapy
Gimeracil and Oteracil Porassium
