摘要
目的探讨外周血中性粒细胞/淋巴细胞比值(NLR)在评估心力衰竭(心衰)患者心功能严重程度方面的价值。方法收集2014年1月~2015年12月于大连大学附属中山医院心脏中心住院的心衰患者195例,计算NLR并测定血常规、血浆N端脑钠肽前体(NT-proBNP)超声心动图,采用相关性分析方法分析NLR与左室射血分数(LVEF)、NT-proBNP及NYHA心功能分级之间的相关关系。再根据NLR水平将患者分为NLR>2.632及NLR<2.632两组,分别对两组患者的基本情况及LVEF、NT-proBNP进行比较;根据NYHA心功能分级将患者分为NYHAⅢ级、Ⅳ级两组,分别对两组患者的基本情况及LVEF、NT-proBNP进行比较。结果相关性分析显示,NLR与NT-proBNP(r=0.435,P=0.006)、NYHA(r=0.368,P=0.021)呈正相关关系,而与LVEF水平(r=-0.438,P=0.005)呈负相关关系。随NLR水平升高,心衰患者的NT-proBNP(P=0.007)及NYHA(P=0.013)分级明显升高,而LVEF水平(P=0.095)则无显著差异。随着NYHA分级水平的升高,NLR(P=0.036)、NT-proBNP(P=0.005)逐渐升高,LVEF(P=0.033)则明显下降。结论外周血NLR水平越高,则心衰患者心功能越差。
Objective To investigate the value of peripheral blood neutrophil-to-lymphocyte ratio (NLR) in reviewing the damage severity of cardiac function in patients with heart failure (HF). Methods The patients with HF (n=195) were chosen from the Cardiac Center of Zhongshan Hospital Affiliated to Dalian University from Jan.2014 to Dec. 2015. The blood routine test and echocardiogram were conducted, and NLR, N-terminal pro-brain natriuretic peptide (NT-proBNP) and NT-proBNP were calculated. The correlation among NLR, left ventricular ejection fraction (LVEF), NT-proBNP and heart function classification of New York Heart Association (NYHA)was analyzed by using correlation analysis method. The patients were divided, according to NLR level, into group 1 (NLR>2.632) and group 2 (NLR<2.632), and the baseline conditions, LVEF and NT-proBNP were compared between 2 groups. The patients were also divided, according to NYHA, into NYHA class Ⅲ group and NYHA class Ⅳ group, and the baseline conditions, LVEF and NT-proBNP were compared between 2 groups. Results The results of correlation analysis showed that NLR was positively correlated to NT-proBNP (r=0.435, P=0.006) and NYHA (r=0.368, P=0.021), and NLR was negatively correlated to LVEF (r=-0.438, P=0.005). As NLR increased,NT-proBNP (P=0.007) and NYHA (P=0.013) also increased significantly, and LVEF (P=0.095) had no significant change. As NYHA increased, NLR (P=0.036) and NT-proBNP (P=0.005) also increased gradually, and LVEF (P=0.033) decreased significantly. Conclusion The higher the peripheral blood NLR level is, the poorer the heart function is in patients with HF.
作者
杨利娟
王筱梅
YANG Li-juan;WANG Xiao-mei(Zhongshan Hospital Affiliated to Dalian University, Dalian 1016000, China)
出处
《中国循证心血管医学杂志》
2017年第1期60-62,共3页
Chinese Journal of Evidence-Based Cardiovascular Medicine
关键词
心力衰竭
中性粒细胞/淋巴细胞比值
左室射血分数
NT-PROBNP
NYHA心功能分级
Heart failure
Neutrophil-to-lymphocyte ratio
Left ventricular ejection fraction
N-terminal pro-brain natriuretic peptide
Heart function classification of New York Heart Association
