摘要
目的：观察口服氨甲环酸片联合氢醌乳膏治疗黄褐斑的疗效。方法：将272例患者随机分为治疗组和对照组。治疗组：162例，口服氨甲环酸片，外用氢醌乳膏；对照组：110例，口服维生素C片，外用氢醌乳膏。治疗4周、8周后观察两组疗效。结果：治疗4周、8周后，治疗组的有效率分别为88.89%和90.74%，对照组的有效率分别为63.64%和67.27%，治疗组有效率明显高于对照组(4周时，χ2=24.903,P＜0.05；8周时，χ2=23.685,P＜0.05)，差异有统计学意义。两组不良反应发生率无统计学差异，均较轻微，停药后均消失。结论：口服氨甲环酸片联合氢醌乳膏治疗黄褐斑疗效确切，安全快速，费用低廉、患者满意度高，值得临床推广应用。
Objective To observe the efficacy of oral tranexamic acid with hydroquinone cream on melasma. Methods 272patients with melasma were divided into two groups randomly, the treatment group( 162 patients) and the control group( 110patients) .Patients in treatment group were treated by oral tranexamic acid with hydroquinone cream, and those in controlgroup were treated by oral vitamin C with hydroquinone cream. Results After 4 weeks and 8 weeks follow-up period, theeffective rates in the treatment group were 88.89% and 90.74% respectively,and those in control group were 63.64% and67.27% respectively. The effective rates in the treatment group were significantly higher than that of control group(4 weeksχ2=24.903, P <0.05; 8 weeks χ2=23.685, P <0.05). No significant difference was observed in the incidence of adverse reactionsbetween the two groups. Conclusion The treatment of oral tranexamic acid with hydroquinone cream on melasma has highlycure rate,lowly adverse reactions rate and highly cost -effectiveness, worthy of clinical application.
作者
尚智伟
刘多丽
王为平
付宏伟
SHANG Zhi-wei;LIU Duo-li;WANG Wei-ping;FU Hong-wei(Clinical Medical School, Henan University of Science and Technology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003,Henan, China)
出处
《中国美容医学》
CAS
2016年第12期72-74,共3页
Chinese Journal of Aesthetic Medicine
关键词
氨甲环酸
氢醌乳膏
黄褐斑
联合用药
疗效观察
tranexamic acid
hydroquinone cream
melasma
drug combination
clinical observation
