摘要
目的分析泌尿生殖道感染患者支原体[解脲脲原体(Uu)和人型支原体(Mh)]的感染情况及其药物敏感性情况,为临床诊疗提供依据。方法将2009年1月至2014年12月1 638例门诊就诊的泌尿生殖道感染患者送检的样本进行支原体培养鉴定及药物敏感性试验。结果 1 638例临床样本中,支原体阳性样本占45.6%(747/1 638),Uu和Mh的阳性率分别为44.4%和9.5%;单纯Uu、单纯Mh、Uu和Mh混合阳性率分别为36.1%、1.2%、8.4%。女性支原体阳性率(48.6%)明显高于男性(20.9%)(P<0.01)。2009至2013年支原体的阳性率呈现逐年上升的趋势,分别为19.3%、29.3%、41.4%、46.9%和56.0%。2014年支原体阳性率为44.2%,明显低于2013年(P<0.05),减少的部分为Uu,Mh感染呈逐年上升的趋势。Uu和Mh对喹诺酮类抗菌药物的敏感性最差,敏感率<20%,而对强力霉素、美满霉素和交沙霉素的敏感性较高,敏感率>70%;Mh对各抗菌药物的敏感率均低于Uu;女性患者Uu、Mh对四环素类和交沙霉素的敏感率明显高于男性患者。结论Mh的感染呈逐年上升的趋势,且Mh多以与Uu混合感染的形式出现,Mh对各抗菌药物的敏感率均低于Uu,这将给支原体感染的治疗带来更大的挑战,应引起临床的高度重视。
Objective To analyze the infection status and drug susceptibility of ureaplasma urealyticum(Uu) and mycoplasma hominis(Mh) among patients with urogenital tract infection,and to provide areference for diagnosis and treatment. Methods Uu and Mh were cultured and identified from 1 638 outpatientswith urogenital tract infection from January 2009 to December 2014,and drug susceptibility test was performedsimultaneously. Results The positive rate of mycoplasma infection was 45.6%(747/1 638). The positive ratesof Uu and Mh infections were 44.4% and 9.5%,respectively. There were 36.1% patients infected only with Uu,1.2% patients infected only with Mh and 8.4% patients infected with Uu and Mh. The positive rate of mycoplasmainfection was higher in females(48.6%) than that in males(20.9%)(P<0.01). From 2009 to 2013,thepositive rate of mycoplasma infection increased in turn from 19.3%,29.3%,41.4%,46.9% to 56.0%. Thepositive rate of mycoplasma infection in 2014 was 44.2%,which was lower than that in 2013(P<0.05),which the positive rate of Uu infection decreased,while that of Mh infection increased year by year. The drugsusceptibility rates of Uu and Mh to quinolones were the lowest(<20%),but those to doxycycline,minocyclineand josamycine were higher(>70%).The drug susceptibility rates of Mh to antibiotics were lower than those ofUu. The drug susceptibility rates of Uu and Mh to tetracycline and josamycine in females were higher than those inmales. Conclusions The positive rate of Mh infection increases year by year,and patients with Mh infection areoften infected with Uu simultaneously. The drug susceptibility of Mh to antibiotics is lower than that of Uu,whichwould bring challenges to treatment. Therefore,clinicians should pay more attention to it.
作者
尧荣凤
李智
沈菊英
徐龙
YAO Rongfeng;LI Zhi;SHEN Juying;XU Long(Department of Clinical Laboratory,Yangpu Hospital of Tongji University,Shanghai 200090,China)
出处
《检验医学》
CAS
2016年第12期1050-1054,共5页
Laboratory Medicine
关键词
解脲脲原体
人型支原体
药物敏感性试验
Ureaplasma urealyticum
Mycoplasma hominis
Drug susceptibility test
