摘要
长链非编码RNA(long non-coding RNA,lnc RNA)是位于真核细胞内,长度超过200nt的不具阅读框的非编码RNA。在哺乳动物基因组中被普遍转录,其表达具有时空特异性。lnc RNA参与X染色体沉默、基因组印记、染色质修饰、转录激活、转录干扰、核内运输等多种重要的调控过程,并与疾病的发生、发展、诊断和治疗有密切的关系。lnc RNA覆盖面之广、潜力之大,使得其成为当今生物学中最热门最前沿的研究领域之一。本文将从lnc RNA的研究历程、来源与分类、作用机制和功能研究、在疾病中的作用这几个方面进行总结和论述。
Located in eukaryotic cells , long non-coding RNA (lncRNA) does not have the reading frame, with a length of more than 200nt. It is widely transcribed in mammalian genome and its expression spatiotemporal specificity. lncRNA takes part in many important regulational processes, such as X chromosome silence, genomic imprinting, chromatin modification, transcription activation, transcription interference, nuclear transport etc. And it's closely related with occurrence, development, diagnosis and treatment of the disease.It has such wide coverage and potential, wrhich makes the study of lncRNA become one of today's most cutting-edge biology of the most popular areas. This article will summarize the history of study, origin and classification, mechanism action and function of lncRNA, and the role of lncRNA in the disease.
作者
吴王亲
张婷
田男
WU Wang-qin;ZHANG Ting;TIAN Nan(College of Life Science, Zhejiang Chinese Medical University, Hangzhou,Zhejiang Province 310053 China)
出处
《世界复合医学》
2016年第1期63-68,共6页
World Journal of Complex Medicine
基金
浙江中医药大学校级基金重点项目(2014ZZ05)
浙江省自然科学基金青年基金项目(no.LQ12C07001)
浙江省教育厅一般科研项目(Y201121464)
国家级大学生创新创业训练计划项目(201410344004)
关键词
长链非编码RNA
疾病
作用机制
诊断
治疗
Long non-coding RNA
Disease
Mechanism of action
Diagnosis
Treatment
