摘要
目的:对肺癌化疗患者发生院内感染病原菌的分布及药敏结果进行分析,为临床抗感染治疗提供依据。方法:对2010年1月至2015年6月收治的采取化学治疗合并医院感染的240例肺癌患者的临床资料进行回顾性分析,对于送检的感染性标本进行病原菌检测及药敏试验,分析感染的部位、感染病原菌的种类、构成比及不同种类病原菌对抗生素的耐药率;采用SPSS 17.0进行数据统计分析。结果:肺癌化疗患者发生院内感染的部位:呼吸道所占比例最高,137例占57.1%,泌尿道感染次之,54例占22.5%;感染病原菌以革兰阴性菌最多,162株占67.5%,革兰阳性菌次之63株占26.3%,真菌15株占6.2%;革兰阴性菌对环丙沙星、哌拉西林、林可霉素、庆大霉素等抗菌药物耐药率较高,革兰阳性菌对青霉素G、林可霉素、庆大霉素等抗菌药物耐药率较高,真菌对氟康唑、氟胞嘧啶有较高的耐药率。结论:对于化疗后合并院内感染的肺癌患者的病原菌分布及药敏结果进行分析,能够促进临床合理使用抗生素,减少耐药菌的产生,对于改善患者的生存质量具有重要意义。
Objective: To investigate the distribution of pathogens nosocomial infections in the lung cancer chemo-therapy patients and analyze drug susceptibility, to provide the basis for clinical treatment. Methods : The clinical data of 240 cases of lung cancer patients, treated with chemotherapy and consolidated nosocomial infection from Jan 2010 to Jun 2015 ,were retrospectively analyzed,to test infectious pathogen and drug sensitive,analysis of the site of infection, infection of pathogenic bacteria types and constituent ratio, and different kinds of pathogenic bacteria to antibiotics re-sistance. Results:Lung cancer chemotherapy patients with highest proportion of parts of the occurrence of nosocomial infection in respiratory tract of 137 cases(57. 1% ),urinary tract infection,accounting for 22. 5% . Infection of patho-genic bacteria in most gram - negative bacteria 162 strains (67.5% ) ,gram - positive bacteria followed 63 strains (26. 3 % ) ,15 fungi strains (6.2%). Gram - negative bacteria to ciprofloxacin, piperacillin, clindamycin, gentamicin antibiotic resistant rate was higher,gram - positive bacteria to penicillin G, clindamycin, gentamycin antibiotic resist-ant rate was higher,Fungi to fluconazole,fluorine cytosine had higher resistance. Conclusion: To merge the hospital infection of patients with lung cancer after chemotherapy pathogenic bacteria distribution and drug susceptibility re-sults were analyzed,and to promote the clinical rational use of antibiotics,reducing the generation of drug - resistant bacteria,is of great significance to improve the patients quality of life
作者
慕玉东
王永兴
杨瑞繁
Mu Yudong;Wang Yongxing;Yang Ruifan(Department o f Clinical Laboratory ^Shaanxi Province Cancer Hospital y Shaanxi X ian 710061,China)
出处
《现代肿瘤医学》
CAS
2016年第14期2244-2246,共3页
Journal of Modern Oncology
基金
陕西省自然科学基础研究计划项目(编号:2012JM4006)
关键词
肺癌
化疗
院内感染
耐药性
lung cancer ,chemotherapy,nosocomial infections,drug resistance
