摘要
喹啉衍生物是一类重要的杂环类药物,其中4-氨基喹啉衍生物可以作为痛敏肽拮抗剂,而4-氨基-6-硝基-3-溴喹啉是制备4-氨基喹啉衍生物的前体。本文以4-硝基喹啉N-氧化物为原料,在醋酸的作用下,经铁粉还原反应生成4-氨基喹啉;再经溴代反应生成4-氨基-3-溴喹啉;最后经混酸硝化反应生成4-氨基-6-硝基-3-溴喹啉。化合物结构用1H-NMR、13C-NMR、IR、MS表征。
Quinoline derivatives are an important class of heterocyclic pharmaceuticals. 4-amino quinoline derivatives were used asnociceptin antagonists,and 4-amino-3-bromo-6-nitroquinoline is precursor to prepare it. Using 4-nitroquinoline N-oxide as the sartingmaterial,4-aminoquinoline was prepared throuh the reaction of nitroreduction by iron powder with acetic acid condition. Following,4-amino-3-bromo-quinoline was obtained by bromine. Finally,4-amino-3-bromo-6-nitroquinoline was synthesis by nitration reactionwith mixed acid. The chemical structures were characterised by 1 H-NMR,13 C-NMR,IR and MS.
作者
王雅珍
林伟
WANG Ya-zhen*;LIN Wei(School of Chemistry and Environmental Engineering,Jiangsu University of Technology, Changzhou 213001,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2016年第8期1150-1154,共5页
Chemical Research and Application
