摘要
毛果芸香碱[简称Pilo,其模型化合物甲基味唑(简称MID)]与过氧化苯甲酰(BPO)组成的氧化还原引发体系能在较温和的条件下引发烯类单体聚合,形成控释给药药膜,从而避免了在剧烈条件下聚合成型可能导致药物结构受破坏,又可避免一般含小分子胺的氧化还原引发体系的引入。实验证明:BPO-Pilo、BPO-MID体系的活化能分别为66.9kJ/mol和74.3kJ/mol(40～60℃),低于纯BPO体系的活化能;且BPO-Pilo体系能在40℃温度下引发烯类单体聚合,形成控释药膜,该药膜能在兔眼中维持缩瞳应8天之久。
This paper deals with a new type of redox initiator-drug/peroxide initiator, which can be applied in controlled drug delivery system and is helpful to develop peroxideheterocyclic tertiary amine redox system. In this paper, we reported about the investigation of kinetics of polymerization of MMA intiated by BPO-Pilocarpine (Pilo) and BPO-methylimidazole(MID) (the model compound of Pilo). We used 'BPO-Pilo' to initiate comonomers HEMA-MMA and obtained drug-membrane. Polymerization was carried out at 40℃. Results of some in vitro and in vivo drug releases were obtained.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1991年第3期66-71,共6页
Journal of Jinan University(Natural Science & Medicine Edition)
