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慢性便秘胃肠激素的变化 被引量:9

The Changes of Gastrointestinal Hormones in Chronic Constipation
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摘要 目的 研究慢性便秘胃肠激素的变化。方法 门诊慢性便秘患者 17例 ,正常对照 10例 ,空腹采血 ,采用RIA法检测生长抑素 (SS)和P物质 (SP)的水平。结果 慢性便秘患者SS和SP的水平分别为 (12 0 5 7±2 7 84 )pg/ml及 (7 6 8± 2 5 )pg/ml。与对照组比较 ,差异有显著性 (P <0 0 1)。结论 胃肠激素的变化在慢性便秘的发病中起着一定的作用。 Objectives To study the changes of gastrointestinal hormones in chronic constipation. Methods 17 outpatient chronic constipation patients, and 10 normal persons were respectively chosen as observation group and control group. Fasting blood samples were taken in all patients. The serum levels of somatostatin (SS) and substance P (SP) were tested using RIA method.Results The serum level of SS and SP in observation group were (120.57±27.84)pg/ml and (7.68±2.5)pg/ml respectively, significantly higher than that in control group (P<0.01).Conclusions The changes of gastrointestinal hormones might play some roles in the pathogenesis of chronic constipation.
出处 《中国医师杂志》 CAS 2002年第10期1081-1081,1083,共2页 Journal of Chinese Physician
关键词 RIA法 胃肠激素 慢性便秘 生长抑素 P物质 发病机制 Constipation chronic Gastrointestinal,hormones
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  • 1柯美云 见:潘国宗 曹世植 主编.便秘[A].见:潘国宗,曹世植,主编.现代胃肠病学[M].北京:科学技术出版社,199.273-74. 被引量:1
  • 2el-Salhy-M, Norrgard-O. Coloinc neuroendocrine peptide levels in patients with chronic idiopathic slow transit constipation[J]. Ups J Med Sci, 1998, 103(3):223~30 被引量:1
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  • 4杨云生,冯福才,潘德寿,周殿元,张万岱,张振书.肠易激综合征回盲部肥大细胞及结肠粘膜中胃肠激素的研究[J].中华消化内镜杂志,1997,14(3):149-152. 被引量:21
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  • 6Chang FY, Lee SD, yeh GH, et al. Rat gastrointestinal motor responses mediated via activation of neurokinin receptors[J]. J Gastroenterol Hepatol, 1999, 14(1):39~45 被引量:1

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