摘要
目的 总结我院 1997年 9月至 2 0 0 1年 9月 4例同种原位心脏移植的经验和教训。方法 4例终末期扩张性心肌病病人接受了标准式心脏移植 ,其中 1例术中采用了右心转流技术。儿童心脏移植克服了术后高心排带来的不良影响。免疫抑制剂应用三联方案加减。结果 4例均顺利完成手术 ,术后早中期死亡 2例。 2例长期存活 ,供心功能良好。结论 心脏移植是治疗终末期扩张性心肌病的有效治疗方法 ,合理的选择供体 ,术中加强心肌保护是提高存活率的关键 ,术后应加强对霉菌感染的预防、监测和治疗 ,可进一步提高心脏移植的治疗效果。
Objective To sum up the clinical experience of orthotopic cardiac transplantation for severe dilated cardiomyopathy. Methods Standard orthotopic cardiac transplantation was performed in 4 patients with dilated cardiomyopathy from 1997 to 2001. Right heart shunt was performed in one case. Harmful effects caused by high cardiac output following operation was conquered in one child case. The triple immunosuppressive agent treatment was applied following operation. Results All patients survived operation. There was 1 early death within 1 week and 1 late death 1 month after operation. The other 2 cases were followed up for 5 months to 4 years respectively. Clinical conditions, cardiac function, quality of life in survival patients were improved significantly. Conclusion Cardiac transplantation is an effective treatment for severe dilated cardiomyopathy. Proper selection and better preservation of donor hearts are essential to improve the long term survival. Enhance monitor, prevention and treatment of fungal infection after operation might improve long term outcome.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2002年第10期1239-1240,共2页
Journal of Third Military Medical University
