摘要
目的探讨盐酸克林霉素(简称克林霉素)单独使用及与喜炎平注射液合用治疗小儿急性化脓性扁桃体炎的安全性及有效性。方法选取100例急性化脓性扁桃体炎患儿为研究对象,随机分为观察组(n=50)和对照组(n=50)。对照组仅给予克林霉素,观察组给予喜炎平联合克林霉素。比较两组患儿临床症状消失时间、血清促炎因子表达水平及临床疗效。结果观察组患儿体温复常时间、咽喉疼痛消失时间、扁桃体充血消退时间及脓性分泌物消失时间均显著短于对照组,组间差异具有统计学意义。观察组患儿血清白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)等促炎因子表达水平显著低于对照组,组间差异具有统计学意义。观察组治疗有效率显著高于对照组(98.0%vs 78.0%),组间差异具有统计学意义。结论喜炎平联合克林霉素治疗小儿急性化脓性扁桃体炎的效果优于单纯克林霉素治疗,抑制机体促炎因子表达是其可能作用机制。
OBJECTIVE To evaluate the effect and safety of Clindamycin alone or combined with Xiyanping injection on acute suppurative tonsillitis in children.METHODS A total of 100 children with acute suppurative tonsillitis were randomly divided into observation group(n=50) and control group(n=50).The Clindamycin alone was used in control group.The Clindamycin combined with Xiyanping injection were used in observation group.The clinical symptom disappeared time,serum proinflammatory cytokine and clinical efficacy were compared between the two groups.RESULTS The duration of hyperthermia,pharyngalgia,antiadoncus and purulent secretion in observation group were significantly shorter than that in control group.The level of interleukin-6(IL-6),interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α)in observation group were significantly lower than that in control group.The clinical efficacy in observation group were significantly higher than that in control group(98.0%vs 78.0%).CONCLUSION The efficacy of Clindamycin combined with Xiyanping injection for acute suppurative tonsillitis in children is better than Clindamycin alone.The inhibition of the proinflammatory cytokine expression may be its possible mechanism.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2015年第4期204-206,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
基金
广东省科技计划项目(2010A030400010)
关键词
扁桃体炎
克林霉素
病例对照研究
儿童
促炎因子
Tonsillitis
Clindamycin
Case-Control Studies
Child
proinflammatory cytokine
