摘要
目的:对比研究生长抑素衍生物善宁(Sandostatin)加倍剂量治疗重症急性胰腺炎(SAP)与常规剂量治疗SAP的疗效.方法:实验用5%牛黄胆酸钠和牛胰蛋白酶混合液胰管注入,制备犬SAP模型.分3组:重症急性胰腺炎组(SAP,6)、25μg/h治疗SAP组(SAP1,6)和50μg/h治疗SAP组(SAP2,6).SAP1、SAP2组于模型制备后分别以25μg/h和50μg/h持续静脉滴注善宁72h(在滴注前均静脉注射善宁0.1mg),动态观察各组以下指标:血清淀粉酶、磷脂酶A2(PLA2)、血栓素A2(TXA2)、前列腺素I2(PGI2)、内皮素(ET)、一氧化氮(NO)、细胞因子(TNFα、IL-1β、IL-6、IL-8、IL-10、IL-1ra)、血小板活化因子(PAF)和内毒素,并计算各组在72h内的死亡率.结果:SAP1组与SAP组相比,仅有血清淀粉酶、PLA2显著降低(P<0.05);SAP2组与SAP组相比,随着病程进展其血清淀粉酶、PLA2、TXA2、PGI2、ET、NO、TNFα、IL-1β、IL-6、IL-8、IL-10、IL-1ra、PAF和内毒素等各项指标均有显著差异(P<0.01);SAP2组与SAP1组相比,上述各项指标也均有显著差异(P<0.05).SAP2组死亡率(16.7%)与SAP组(83.3%)和SAP1组(66.7%)相比有显著差异(P<0.05).结论:善宁加倍剂量治疗(SAP)的疗效显著优于常规剂量.
AIM:To study the curative effect of sandostatin on severeacute pancreatitis (SAP) with routine and doubling dosage.METHODS:Eighteen dogs were divided randomly into threegroups: SAP group (SAP, n =6) , therapeutic group of SAPwith 25 μg/h (SAP1, n =6) and therapeutic group of SAPwith 50 μg/h ( SAP2, n =6) . SAP models were establishedby injecting 5 % sodium taurocholate and trypsin into themain pancreatic duct. The dogs of SAP1 and SAP2 groupswere injecting sandostatin intravenously for 72 hours re-spectively with 25 μg/h and 50 μg/h after induction. Thechanges of indexes that are serum amlyase, PLA2, TXA2,PGI2, ET, NO, TNF α, IL-1β, IL-6, IL-8, IL-10, IL-1ra, PAFand endotoxin were dynamically determined after operations.RESULTS: In SAP1 group, the levels of serum amlyase andPLA2 merely decreased more significantly than those in SAPgroup (P <0.05) . There was significantly difference in thelevels of serum amlyase, PLA2, TXA2, PGI2, ET, NO, TNFα,IL-1β, IL-6, IL-8, IL-10, IL-1ra, PAF and endotoxin betweenSAP2 and SAP groups (P <0.01), and so was between SAP2and SAP1 groups (P <0.05).The death rate in SAP2 groupreduced more significantly than those in SAP and SAP1groups (P <0.05).CONCLUSION:The curative effect of sandostatin on SAP with doubling dosage excels more significantly than thatwith routine dosage.
出处
《世界华人消化杂志》
CAS
2002年第10期1157-1161,共5页
World Chinese Journal of Digestology
