摘要
长爪沙鼠经盲肠内接种溶组织内阿米巴滋养体5×10~5/0.5ml,建立实验性肠阿米巴病的动物模型。取肠壁严重病变的上皮组织作电镜观察,可见溶组织内阿米巴的超微结构发生变化,多形核白细胞伴有脱颗粒现象,上皮组织有微小溃疡形成。同时,对溶组织内阿米巴的致病机理进行了讨论。
In this study, Mongolian gerbil was used as an experimental model for the study on intestinal amoebiasis. Entamoeba histolytica infection was established by intracecal inoculation of 5×105/0.5ml amoabie supension inoculum. Electron microscopies were used to observe the pathological characteristics of intestinal amoebiasis and morphological structure of trophozoites of Entamoeba histolytica in the intestinal mucus. The results showed that the polymorphonuolear leukocyte at the site of lesion evidently degranuled, microuloers formed between the intestinal epithelia, and revealed that the action that the polymorphonuclear leukocyte disrupted the membrane of the intestinal epithelium put an important role in. causing the inflammatory reaction. We could conclude that the self-dissolution, the thread-like filopodia and the food cup of Entamoeba histolytica were maybe the ways in which Entamoeba histolytica released enzymes and toxins, and the pathogenicity of Entamoeba his-tolytica included the phagocytosis, the release of toxins and the promotion of the inflammatory reaction of host.
出处
《上海医科大学学报》
CSCD
1991年第4期266-268,T015,共4页
Journal of Fudan University(Medical Science)
基金
国家自然科学基金(编号 3860958)
关键词
阿米巴病
超微结构
Entamoeba histolytica
intestinal amoebiasis
microulcer
food cup
