摘要
根据多点氢键识别原理 ,设计合成了新的分子钳受体 1～ 6 .研究了其对巴比妥、尿素、二苯甲酮、戊二酰亚胺等中性分子的识别性能 .用差紫外光谱法测定了结合常数和自由能变化 (ΔG) .结果表明 ,所有分子钳受体与所考察的客体分子均形成 1∶1型超分子配合物 ,识别作用的推动力主要为多重氢键的协同作用 .讨论了主客体间尺寸 /形状、几何互补等因素对形成超分子配合物的影响 .并利用1HNMR。
Six molecular tweezers (1～6) have been s yn thesized based on the incorporation of multiple hydrogen-bonding groups into th e cleft to provide both orientation and selective complexation of substrate. Mol ecular recognition properties of these receptors for barbiturate, urea, diphenyl methanone and glutarimide have been investigated by UV-visible spectroscopic ti tration, which indicates that the supramolecular complexes consist of 1∶1 host and guest molecules. The main driving forces are the multiple hydrogen bonding i n molecular recognition. The molecular recognition ability is discussed from the viewpoint of the size/shape-fit and geometrical complementary relationship. Co mputer-aided study and ~1H NMR spectroscopy have been employed to elucidat e the binding behavior of these molecular tweezers.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2002年第10期1841-1845,共5页
Acta Chimica Sinica
基金
国家自然科学基金 (No .2 0 0 72 0 2 6)资助项目
