摘要
洛索洛芬钠是一种副作用小、疗效高的非甾体类抗炎镇痛药。在总结前人工作的基础上 ,对其合成工艺中的重要中间体 2 (4 氯甲基苯基 )丙酸乙酯的合成进行了改进 ,以催化剂四氯化钛替代四氯化锡 ,取得了很好的效果 ,总收率为 5 8% (原文献收率为 36 % )。
Loxoprofen sodium is a kind of a non steroid anti inflammatory and antalgic drug with less side effects and high effect.In this article,the synthesis of the most important intermediate ethyl [ p (chloromethyl)phenyl]propionate in the synthetic route of loxoprofen sodium was improved based on the previous research.The catalyst TiCl 4 instead of SnCl 4 was used in the experiments,and a wonderful result was obtained.The overall yield was increased from 36% to 58%.
出处
《中国药物化学杂志》
CAS
CSCD
2002年第5期292-294,共3页
Chinese Journal of Medicinal Chemistry
关键词
非甾体抗炎药
洛索洛芬钠
合成
steroid anti inflammatory
loxoprofen sodium
synthesis
