摘要
目的 探讨大鼠心脏连接蛋白 4 3(Cx4 3)表达的增龄变化规律。 方法 应用SP免疫组织化学方法 ,检测 2 1例幼年组、青年组和老年组大鼠心肌细胞Cx4 3的蛋白表达。 结果 1 Cx4 3主要在心室肌表达。 2 幼年大鼠心室肌的Cx4 3多数已聚集于端闰盘处 ,少数仍呈斑点状散在分布 ,而乳头肌等处的Cx4 3主要分布于细胞表面。青年和老年大鼠的Cx4 3典型地分布于端闰盘处。 结论 Cx4
Objective To investigate the change of Connexin43 expression in rat heart as age advancing. Methods The expressions of Connexin43 in different age of rat heart were determined by immunohistochemistry. Results 1\^ The expression of Connexin43 was only seen in ventricular myocardium. 2\^ The Connexin43 immunolabelling of infant rat heart lie much more within the transversely orientated intercalated disk, besides, a fewer have a punclate distribution over the entire surface of the ventricular myocytes, and Connexin43 distributed mainly on the myocyte surface of the parpillary muscles. Connexin43 immunolabelling of young and old rat heart are typically confined to the site of intercalated disk.Conclusion The expressions of Connexin43 are different in different age and different parts of rat heart.
出处
《解剖学报》
CAS
CSCD
北大核心
2002年第5期550-552,共3页
Acta Anatomica Sinica
