摘要
目的 检测血清中绒毛膜促性腺激素 (β hCG) ,孕酮 (P) ,白血病抑制因子 (leukemiainhibitoryfactor,LIF)水平 ,评估其对早期异位妊娠的诊断价值。方法 选取异位妊娠患者 15例作为EP组 ;先兆流产患者 15例作为TA组 ;正常宫内妊娠30例作为对照 (NIUP)组。采用RIA法测血清β hCG、P水平 ,采用ELISA法测血清LIF水平。 结果 EP、TA、NIUP各组β hCG水平分别为 80 6 5 6± 2 4 81 2IU/L、982 5 4± 2 74 1 3IU/L、2 5 0 6 8 6± 316 4 8IU/L ;P水平分别为 11 4± 6 3ng/ml、11 6± 4 1ng/ml、2 7 5±8 6ng/ml;NIUP与TA、EP各组间差异有显著性 (P <0 0 1)。LIF水平分别为 5 6 4± 0 6 6pg/ml、7 14± 0 4 2pg/ml、6 14±1 4 7pg/ml;EP与TA组差异有显著性 (P <0 0 1)。结论 单次检测血清 β hCG对早期异位妊娠无鉴别诊断意义 ;检测血清P水平有助于鉴别正常妊娠与异常妊娠 ;检测血清LIF水平有助于鉴别异常宫内妊娠与异位妊娠 ;联合检测β hCG、P、LIF可作为临床早期诊断异位妊娠高效、有力、敏感的指标。
Objective To evaluated the value of β hCG?P?LIF lavels in Diagnosis of Early Ectopic Pregnancy Methods The sera levels of β hCG?P?LIF were measured by RIA and ELISA respectively 15 specimens of ectopic pregnancy,15 specimens of threatened abortion and 30 specimens of normal pregnancy were study group(EP),control group(TA) and normal control group(NIUP) respectively Results In EP?TA and NIUP group the Level of β hCG is 8065 6+-2481 2 IU·L -1 ?9825 4±2741 3 IU·L -1 ?25068 6+3164 8 IU·L -1 respectively And the Level of P is 11 4+6 3 ng·ml -1 ?11 6±4 1 ng·ml -1 ?27 5±8 6 ng·ml -1 respectively;There are significantly different between NIUP and EP/TA group(P<0 01) The Level of LIF is 5 64±0 66 pg·ml -1 ?7 14±0 42 pg·ml -1 ?6 14±1 47 pg·ml -1 respectively;There are significantly different between TA and EP group (P<0 01) Conclusion Only once measured theβ hCG level is not sufficiently discriminatory to diagnose ectopic pregnancy P level is helpful to distinguise normal pregnancy and abnormal pregnancy LIF level is very helpful to distinguise threatened abortion and ectopic pregnancy β hCG ?P?LIF would be very valuable for the clinical diagnosis of early ectopic pregnancy
出处
《中国医刊》
CAS
2002年第10期27-28,共2页
Chinese Journal of Medicine
