摘要
目的 :通过数量化脑电图 (QEEG)和临床指标监测探讨纳洛酮治疗急性重型脑外伤的疗效。方法 :对 39例急性重型脑外伤患者进行随机、双盲治疗。前 3天剂量为每日 0 .3mg/kg ,后 7天剂量为 4 .8mg/d ,观察生命体征、头颅CT变化 ,连续监测数量化脑电图。揭盲后分为纳洛酮治疗组和对照组进行统计学分析。结果 :纳洛酮治疗组早期病人呼吸循环较快恢复稳定 ,呼吸异常 (33.3% )、心律异常 (38.1% )和重度脑水肿者(2 2 .6 % )均较对照组明显减少 (P <0 .0 5 ) ;纳洛酮治疗组早期病人双频谱指数 (Bispectralindex ,BIS)较对照组明显增高 (P <0 .0 5 ) ,1周后BIS达 90以上者 12例 (5 7.1% ) ,高于对照组 7例 (38.9% ) (P <0 .0 5 ) ,且BIS的升高与GCS评分变化一致。结论 :纳洛酮能有效改善急性脑外伤患者异常的数量化脑电图指标 ,对于急性重型脑外伤有明显的治疗作用。
Objective:Quantitative Electroencephalographical study on effect of Naloxone on acute severe head injuries.To evaluate the effect of naloxone with quantitative electroencephalogram (QEEG) on acute head severe injuries.Methods: A double-blind clinical trial of naloxone in which 39 patients with severe head severe injuries were treated with either naloxone or normal saline for ten days was undertaken. The patients fallen randomly into the naloxone-treating group were given intravenously 0.3mg/kg·d naloxone hydrochloride for the first three days and 4.8mg/d naloxone hydrochloride for the following seven days. The clinical data and QEEG peritreatment were observed. Results:The fluctuation of vital signs in the first 3 days was smoother in naloxone group than that in control, including arrhythmia ( P <0.05)and abnormal respiration ( P <0.05).CT scanning showed that the severity of brain edema was less remarkable ( P <0.05) after treatment of naloxone for one week. Bispectral index (BIS) after administration of naloxone were increased significantly and different statistically from those of the control group ( P <0.05). More patient revived in naloxone group than that in control ( P <0.05) in 7 days accompanied by higher BIS volume (BIS>90). Conclusions: These results indicate that naloxone is beneficial in the treatment of severe head injuries in terms of improved quantitative electroencephalogram.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第19期43-45,共3页
China Journal of Modern Medicine
