摘要
目的 :探讨抗氧化药辅助治疗精神分裂症的疗效。方法 :将 80例精神分裂症患者随机双盲分为治疗组和对照组各 40例 ,治疗组给予抗氧化药 (维生素C 2 0 0mg及维生素E 10 0mg)联合利培酮 ,对照组安慰药合并利培酮 ;抗氧化药和安慰药用法相同 ,均tid ,po。两组患者开始给利培酮 1mg·d 1,午饭后服用 ,渐增至 3～ 6mg·d 1,治疗组最高剂量(4 .5 2± 0 .3 9)mg·d 1,对照组最高剂量 (4 .5 4± 0 .3 9)mg·d 1,两组用量差异无显著性 (P >0 .0 5 )。治疗 12周进行比较。采用阳性和阴性症状量表 (PANSS)评定疗效 ,用不良反应量表和锥体外系不良反应量表评定不良反应。结果 :两组之间疗效差异无显著性 (P >0 .0 5 )。在认知因子、阴性因子、PANSS总分减分率方面 ,治疗组优于对照组 (P >0 .0 5 )。对照组出现锥体外系不良反应例数偏高。结论 :抗氧化药辅助抗精神病药物治疗精神分裂症 ,在认知功能和阴性症状方面确定有效 。
Objective:To probe into the therapeutic effectiveness of risperidone in combination with antioxidants in the treatment of schizophrenia. Method:80 patients with schizophrenia were randomly divided into 2 groups with the double blind method. Patients of the treatment group( n =40) were given risperidone in combination with antioxidants (vitamin C 200 mg/dose/case and vitamin E 100 mg/dose/case) while patients of the control group ( n =40) were treated with risperidone and placebo. Both antioxidants and placebo were administerd PO, tid. The intial dose of risperidone for patients of both group was 1 mg·d 1 , taken after lunch. The dose was then gradually increased to 3～6 mg·d 1 . The highest dosages for patients of the treatment group and control group were 4.52±0.39 mg·d 1 and 4.54±0.39 mg·d 1 , respectively. The difference was insignificant ( P >0.05). The situations of patients of the 2 groups were compared after 12 weeks of treatment. The therapeutic effectiveness was assessed with PANSS and the side effects were evaluated with TESS and ESRS. Results:The difference between the therapeutic effects of the 2 groups was insignificant( P >0.05). However the congnitive factor, negative factor and decreasing rate of PANSS in patients of the treatment group were superior to those of the control group( P <0.05). The side effects included extrapyramidal motor symptoms (Eps), hepatosis and insommia. Conclusion:Risperidone in combination with andantioxidants was found to be definitely effective in improving congnitjue function and relieving negative symptom in the treatment of schizophenia. The treatment could also decrease side effects of antipsychotics.
出处
《医药导报》
CAS
2002年第10期629-630,共2页
Herald of Medicine
