摘要
观察了生脉注射液对大白鼠造影剂相关肾病(Contrast Medium-AssociatedNephropathy,CAN)的影响。结果:在灌注泛影葡胺前加用生脉注射液,血清尿素氮、血清肌酐,肾组织磷脂酶 A_2(phospholipase A_2,PLA_2)活性、钙离子含量均明显低于模型对照组(P<0.01),病理损害明显改善。提示:生脉注射液对大白鼠 CAN 有保护作用。其机理可能与抑制PLA_2活性、拮抗钙内流,扩肾血管有关。
The effects of Shengnai injection（SMI）on the prevention of contrast medium-associated nephropathy（CAN）were studied in Sprague-Dawtey（SD）rats.Twenty SD rats were randomly divided into two groups（10/group）,The results showed:In the group pretreated with SMI,either in the levels of blood urea nitrogen and serum creatinine or in the renal phospholipase A<sub>2</sub> activ- ity and calcium levels were significantly lower than thee in the control group（all P<0.01）.The renal injuries induced by dia- trizoate were alleviated.The results suggested that SMI could protect renal tissue from CAN in the SD rats.The mechanism might relate to its preventing intracellular calcium accumulation,inhibiting PLA<sub>2</sub> activity and dilating renal vascularity.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第S1期101-103,287,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
生脉注射液
造影剂
泛影葡胺
肾毒性
肾病
肾功能衰竭
nephropathy
contrast media
Shengmai injection
renal failure
nephrotoxicity
diatrizoate
