摘要
对白血病细胞染色体研究表明 ,一些特异的细胞遗传学改变和急性非淋巴细胞白血病 (ANLL)亚型有很大的相关性。T(16 ;2 1)易位是非常罕见的 ,可能与急性非淋巴细胞性白血病中一类很独特的白血病亚型有关的易位 ,易位发生在 2 1号染色体的长臂和 16号染色体的短臂 ,与此易位相关的是 2 1号染色体的ERG基因和 16号染色体的TLS/FUS基因 ,当发生易位时形成TLS/FUS -ERG融合基因并产生相应的转录本。迄今为止国外仅报道 39例t(16 ;2 1) ,(p11;q2 2 )患者 ,我们发现 1例小儿有此类染色体易位 ,其染色体该型为 4 6 ,xx ,t(16 ;2 1) ,(p11;q2 2 ) / 47,xx ,+ 8,t(16 ;2 1) (p11;q2 2 ) ,TLS/FUS
Chromosome banding studies of leukemia cells have revealed an association between specific cytogenetic changes and subtypes of acute nonlymphocytic leukemia. The t(16;21)(p11;q22) translocation is a rare but recurrent chromosomal abnormality seems to be associated with unique subtypes of acute nonlymphocytic leukemia. A reciprocal translocation was found between the long arm of chromosome 21 and the short arm of chromosome 16. The genes involved in this translocation are ERG on chromosome 21and TLS/FUS on chromosome 16. The rearrangement of the two chromosomes forms the TLS/FUS-ERG fusion gene and produces a chimdric transcript. There have so far been only 39 reported cases of t(16;21)(p11;q22) translocation out of the country. We report on a child with t(16;21)(p11;q22). The karyotypes were 46,xx, t(16;21)(p11;q22) and 47,xx, +8, t(16;21)(p11;q22). The TLS/FUS-ERG fusion gene chimeric transcript is positive. Taking reported documents into account, the clinical and lab data of these patients are reported as follows.
出处
《中国小儿血液》
2002年第4期153-155,共3页
China Child Blood
