摘要
用定量手指甲襞毛细血管显微镜对25例I型糖尿病患者和27例正常人(对照)进行测量,最后的6个病人和7例健康者做手指甲襞活组织检查。体内毛细血管襻宽度作为毛细血管襻变形参数的结果表明,在糖尿病患者其数值明显高于正常人。组织病理检查表明,糖尿病病人甲襞皮肤乳头胶原沉积明显增加,胶原的沉积与糖尿病患者的甲襞皮肤乳头毛细血管内皮细胞数量和乳头大小相关。由此认为,糖尿病性微血管病,除甲襞毛细血管变形外,胶原沉积可能是代谢紊乱和毛细血管内皮细胞增殖的一个表现。
Quantitative finger nailfold capillary microscopy was performed in 25 patients with type Ⅰ diabetes and in 27 healthy control subjects. In the last consecutive 6 patients and 7 controls of these populations, finger nailfold biopsies were taken. Measurements of loop width as an in vivo parameter for deformities of the capillary loops showed significantly higher values in diabetic patients than in controls. Histopathological examination showed markedly and signifieantly increased deposition of collagen in nailfold dermal papillae of the diabetic patients. The deposition of collagen was positively correlated with the number of capillary endothelial cells in the nailfold dermal papillae and with the size of the papillae in diabetic patients. It is concluded that, in addition to deformity of nailfold capillaries, collagen deposition may also be a sign of metabolic disturbance and perhaps of proliferation of capillary endothelial cells in diabetic mieroangiopathy.
出处
《中国微循环》
1993年第1期2-7,共6页
Journal of Chinese Microcirculation
关键词
手指甲襞
毛细血管显微镜
甲襞活检
毛细血管变形
胶原沉积
Finger nailfold—Capillary microseopy—Nailfold biopsy—Capillary deformity—Collagen deposition
