摘要
对近年来有关蛇床子素脑缺血保护作用研究的报道进行分析,发现其不仅能抑制脑缺血再灌过程中的炎性反应、减轻脑水肿而保护受损脑组织,还能增加缺血脑组织中抗氧化酶的活性,清除氧自由基而减少再灌过程中自由基带来的损伤。此外蛇床子素还具有良好的抗凝抗血栓作用,该文从抗炎、抗氧化、抗凝、抗凋亡等几个方面综述蛇床子素发挥保护作用的可能机制,以期为进一步研究蛇床子素防治脑缺血的药理作用提供参考。
In this paper,the publication of osthole in protecting brain ischemia were retrieved and summarized. Our analysis found that osthole can not only decrease the cerebral ischemia reperfusion injury by inhibiting the inflammation reaction and lowering cerebral edema,but also increase the activity of antioxidant enzymes in the ischemic tissue of the brain,scavenge oxygen free radicals and reduce ischemia reperfusion injury caused by free radicals.Furthermore,osthole also exhibited a good anticoagulant effect. So the possible mechanisms of the protective role of osthole were reviewed from anti-inflammatory,anti-oxidation,anti-coagulant,anti-apoptotic and other aspects,in order to provide support for the further pharmacological studies of osthole in brain cerebral ischemia.
出处
《神经药理学报》
2012年第2期42-47,共6页
Acta Neuropharmacologica
基金
国家国际科技合作项目(No.2010DFB32900)
国家自然科学基金(No.81173578
No.81274122)
国家"重大新药创制"科技重大专项(No.2012ZX09103101-006
No.2012ZX09301002-004)
教育部创新团队(No.IRT1007)
北京市自然基金(No.7131013)
关键词
蛇床子素
脑缺血
炎症
抗氧化
抗凝
osthole
brain ischemia
inflammation
anti-oxidation
anti-coagulant
