摘要
目的 研究表阿霉素与中药抗癌剂鸦胆子油、碘油制成超液化乳剂(简称YLEE)治疗肝癌的临床价值。 方法 1987年12月～1990年12月间治疗的原发性肝癌286例。行肝动脉化疗栓塞共450人次。最短随访时间1年。全部采用Seldinger′s方法,应用超选择肝叶和肝段动脉插管。本组病例按以下分组分析疗效:(1)化疗+单纯碘油表阿霉素乳剂栓塞(HAI+HAEⅠ);(2)化疗+YLEE栓塞(HAI+YLEE)。 结果 本治疗组10例大肝癌治疗后肿块缩小率达到50%以上,二期切除病理显示:肿瘤区域细胞全部凝固性坏死,边缘有淋巴细胞浸润。286例患者治疗后一年、二年生存率分别为552%和345%(北方代表组为423%和77%;南方代表组为353%和250%)。8例生存3年,3例生存5年,其中1例已生存10年,目前仍在随访中。 结论 利用鸦胆子具有栓塞、抗肿瘤和载体三重作用,与表阿霉素、碘油制成“双载体”、“双弹头”的油包水剂型,具有很好的稳定性,加强了杀伤癌细胞、栓塞末梢血管的作用。
PURPOSE To study the clinical value of the interventional therapy of primary liver cancer by ultraliquidized emulsion of epirubicin and YDZ,the Chinese medical anti cancer agent(YLEE).METHODS 286 cases of primary hepatic carcinoma were treated by hepatic arterial chemoembolication from December 1987 to December 1990,totally 450 times.The duration of follow up is noless than one year. A super selective catheterization to hepatic lobe and hepatic segmeat was conducted by seldinger′s method in all cases. An analysis of prognosis was done according to groups divided as follows:(1)hepatic arterial infusion chemotherapy+epirabicin lipidol emulsion embolization (HAI+HAE Ⅰ);(2)hepatic arterial infusion chmotherapy+YLEE embolization (HAI+YLEE).RESULTS The response rate of ten cases of huge primary hepatic carcinoma in the group was 50%. Subsequent surgical histopathology suggested that cellular solidifying necrosis was found in all the field of the tumor and that lymphacyte infiltration developed at that surrounding of the filed.The 1 ,2 year survival rate of the 286 cases were 55.2% and 34.5% respectively.(the North group were 42.3% and 7.7% respectively,and the South group were 35.3% and 25.0% respectively).Eight patients survived 3 years,three patients survived 5 years and one patient is still alive after 10 years of follow up.CONCLUSIONS The triple effects of embolization,anti cancer and carrying of YDZ can be utilized to form.With epirubicin and lipiodol.To form a “double carriers”,“double bullets” oil enveloped water form of agent,which possesses a good stability, and enforced cancer cellulicidal effect and terminal blood vessels embolization,and an easy acceptance of mid advanced hepatic cancer patients.
出处
《中国癌症杂志》
CAS
CSCD
1999年第Z1期35-37,52,共4页
China Oncology
基金
江苏省社会发展基金!资助课题 (编号BS970 2 5)
关键词
介入治疗
肝癌
末梢动脉化疗栓塞乳剂
Interventional therapy Primary hepatic carcinoma Terminal arterial chemoembolization emulsion.
