摘要
目的观察超敏C反应蛋白、纤维蛋白原和D-二聚体在结缔组织病相关间质性肺炎(CTD-ILD)和非结缔组织病相关间质性肺炎(NCTD-ILD)患者血浆中的浓度高低,探究其相关性及临床意义。方法选取2010年1月~2016年4月南方医科大学珠江医院收治的间质性肺炎患者69例,分为CTD-ILD组(30例)和NCTD-ILD组(39例)作为研究对象,同期纳入25例健康人作为对照组,行超敏C反应蛋白、纤维蛋白原和D-二聚体检测。结果 CTD-ILD组和NCTD-ILD组的超敏C反应蛋白、纤维蛋白原和D-二聚体浓度均高于对照组(P<0.05);CTD-ILD组的超敏C反应蛋白浓度高于NCTD-ILD组(P<0.05),但两组间的纤维蛋白原和D-二聚体浓度无差异;超敏C反应蛋白浓度分别与D-二聚体浓度、纤维蛋白原浓度呈正相关(r分别为0.539、0.534,P<0.01)。结论超敏C反应蛋白、纤维蛋白原和D-二聚体对间质性肺炎的临床诊断有重要意义,超敏C反应蛋白的明显升高与合并结缔组织病相关。
Objective To investigate the clinical significance of plasma levels of hypersensitive C-reactive protein(hs-CRP),fibriogen and D-dimmer(D-DI) in patients with connective tissue disease(CTD)-related interstitial lung disease(CTD-ILD).Methods Sixty-nine patients with interstitial lung disease admitted in Zhujiang Hospital between January,2010 and April,2016,including 29 with CTD-ILD and 40 with non-CTD-ILD were analyzed for plasma levels of hs-CRP,fibriogen and D-DI,with 25 healthy subjects as the control group. Results The plasma level of hs-CRP,fibriogen and D-DI in patients with CTDILD and non-CTD-ILD were all significantly higher than those in the control group. The patients with CTD-ILD had a significantly higher hs-CRP level than those with non-CTD-ILD,but the levels of fibriogen and D-DI were comparable between the two groups. Correlation analysis indicated that Hs-CRP level was positively correlated with the levels of D-DI(r=0.539,P<0.01) and fibrinogen(r=0.534,P<0.01). Conclusion Hs-CRP,fibriogen and D-DI levels show an important value in clinical diagnosis of CTD,and an obvious elevation of hs-CRP is correlated with the CTD.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2017年第3期415-419,共5页
Journal of Southern Medical University
关键词
结缔组织病
间质性肺炎
超敏C反应蛋白
纤维蛋白原
D-二聚体
connective tissue disease
intersitial lung disease
hypersensitive C-reactive protein
fibriogen
D-dimmer
