摘要
目的观察氟哌噻吨美利曲辛联合雷贝拉唑治疗反流性食管炎的疗效。方法将2016年7月至2017年7月在本院消化内科治疗的136例反流性食管炎患者随机分为两组,对照组采用雷贝拉唑单药治疗,观察组采用氟哌噻吨美利曲辛联合雷贝拉唑治疗,比较两组患者的临床疗效、症状改善情况、焦虑抑郁改善情况。结果观察组治疗有效率为95.59%,明显高于对照组的79.41%,差异有统计学意义(P<0.05);观察组治疗后反酸、烧心、胸部灼痛、咽喉梗阻感等症状积分明显低于对照组,差异有统计学意义(P<0.05);观察组治疗后HAMA、HAMD评分明显低于对照组,差异有统计学意义(P<0.05)。结论氟哌噻吨美利曲辛联合雷贝拉唑治疗反流性食管炎效果显著,能有效缓解症状,改善心理状态,具有积极的临床意义。
Objective To observe the effect of flupentixol and melittrixine combined with rabeprazole in the treatment of reflux esophagitis. Methods Totally 136 patients with reflux esophagitis treated in our hospital from July 2016 to July 2017 were randomly divided into two groups. The control group was treated with rabeprazole alone,the observation group was treated with flupentixol and melitracin combined with rabeprazole. The clinical efficacy and symptom improvement of the two groups were compared,as well as anxiety and depression state. Results The effective rate of the observation group was 95.59%,which was significantly higher than that of the control group(79.41%,P<0.05). The scores of regurgitation,heartburn,burning pain in chest and feeling of throat obstruction in the observation group were significantly lower than those in the control group(P<0.05). The HAMA and HAMD scores of the observation group were significantly lower than those of the control group(P<0.05). Conclusion Flupentixate and melitracin combined with rabeprazole are effective in the treatment of reflux esophagitis,which could effectively relieve symptoms and improve mental state,and have positive clinical significance.
出处
《大医生》
2018年第Z1期99-100,共2页
Doctor