摘要
目的了解类风湿关节炎(RA)患者外周血巨噬细胞极化与慢性炎症及病情活动的相关性。方法采用流式细胞术检测RA及正常人外周血单个核细胞中M1及M2型巨噬细胞的比例,并分析与RA病情活动指标的相关性。结果 RA患者外周血M2型巨噬细胞比例显著低于健康对照者,与血沉及C反应蛋白、晨僵时间呈负相关。结论外周血巨噬细胞极化的检测有助于RA病情的判断及预后分析。
Objective To investigate the clinical significance of macrophage polarization in rheumatoid arthritis(RA). Methods Macrophage polarization was detected by flow Cytometry in peripheral blood mononuclear cell(PBMC)from RA or normal controls,and the correlation between macrophage number and RA disease activity indicators was analysed. Results The frequencies of M2 macrophages in RA were decreased and there was significant positive correlation between M2 and erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and duration of morning stiffness. Conclusion Macrophage polarization detection is helpful for diagnosing RA disease activity and estimating prognosis.
出处
《大医生》
2017年第9期40-41,82,共3页
Doctor
基金
国家自然科学基金(编号:81701610)
关键词
类风湿关节炎
外周血单核细胞
巨噬细胞极化
rheumatoid arthrits
peripheral blood mononuclear cell
macrophage polarization
