摘要
谷氨酸作为肠上皮主要的能源物质,为肠黏膜生理功能的正常实现(包括营养物质的吸收转运和信号传导的进行以及黏膜上皮细胞的自身更新和高度有序结构的维持)供给能量。同时,其作为一种重要的信号分子和功能性氨基酸,可激活哺乳动物雷帕霉素靶蛋白复合物1(mTORC1)信号通路,参与蛋白质合成,促进细胞增殖,增强肠道抗氧化能力,进而保护肠上皮结构和功能的完整性,促进肠道发育。本文就谷氨酸的吸收转运和代谢系统及其对mTORC1信号通路和动物肠道黏膜屏障功能的影响作一综述,旨在为谷氨酸功能的挖掘及调控动物肠道发育的生产应用提供参考。
As the main energy substrate of intestinal epithelium,glutamate provides energy for normal physiological function of intestinal mucosa,including nutrients absorption and transport,signal conduction,as well as the self-renewal and the maintenance of the highly ordered structure of mucosal epithelial cells.Meanwhile,as an important signaling molecular and functional amino acid,it can activate the mammalian target of rapamycin complex 1(mTORC1) signaling pathway,participate in protein synthesis,induce cell proliferation,enhance intestinal antioxidant ability,and then protect the integrity and function of intestinal epithelium,promote intestinal development.In this paper,we reviewed the research progress of glutamate absorption and transport,metabolic system,and its effect on the mTORC1 signaling pathway and intestinal barrier function,in order to provide useful information for the exploitation of glutamate function and the application of regulation of intestinal development in production practice.
作者
秦颖超
周加义
朱敏
王修启
QIN Yingchao;ZHOU Jiayi;ZHU Min;WANG Xiuqi(National Engineering Research Center for Breeding Swine Industry,Guangdong Provincial Key Laboratory ofAnimal Nutrition Control,College of Animal Science,South ChinaAgricultural University,Guangzhou 510642,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2019年第2期544-552,共9页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金重点项目(31330075)
国家自然科学基金面上项目(31892389)
广州市科技计划项目(201807010001)
关键词
谷氨酸
肠道
吸收转运
屏障功能
调控
glutamate
intestine
absorption and transport
barrier function
regulation
